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https://hdl.handle.net/2440/112316
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Type: | Journal article |
Title: | Performance of serum lipocalin 2 as a diagnostic marker for colorectal cancer |
Author: | Fung, K. Priebe, I. Purins, L. Tabor, B. Brierley, G. Lockett, T. Nice, E. Gibbs, P. Tie, J. McMurrick, P. Moore, J. Ruszkiewicz, A. Burgess, A. Cosgrove, L. |
Citation: | Cancer Biomarkers, 2013; 13(2):75-79 |
Publisher: | IOS Press |
Issue Date: | 2013 |
ISSN: | 1574-0153 1875-8592 |
Statement of Responsibility: | Kim Y.C. Fung, Ilka Priebe, Leanne Purins, Bruce Tabor, Gemma V. Brierley, Trevor Lockett, Edouard Nice, Peter Gibbs, Jeannie Tie, Paul McMurrick, James Moore, Andrew Ruszkiewicz , Antony Burgess and Leah J. Cosgrove |
Abstract: | Background: Lipocalin 2 has been implicated in colorectal tumorigenesis but its usefulness as a diagnostic marker for the disease has previously never been determined. Methods: We have used ELISA immunoassay to measure the level of serum lipocalin 2 in a cohort consisting of colorectal cancer patients (n=196) and age/gender matched controls (n=99). Results: The median concentration of lipocalin 2 was found to be significantly higher (p< 0.0001) in the patient group (105.9 ng/mL, range 10.8-444.7 ng/mL) when compared to the control subjects (86.4 ng/mL, range 17.1-190.0 ng/mL). Additionally, no significant difference was observed between disease stage (Dukes' or T stage) in the patient cohort. Receiver operating characteristic analysis was performed to determine its performance as a diagnostic marker. The area under the curve was found to be 0.641 (95% confidence interval 0.576-0.706). Furthermore, the sensitivity of lipocalin 2 was found to be 24% at 90% specificity. Conclusions: Our study indicates that lipocalin 2 is not a suitable serum biomarker for the diagnosis of CRC. |
Keywords: | Colorectal cancer; biomarker; blood; diagnosis; lipocalin 2 |
Rights: | © 2013 – IOS Press and the authors. All rights reserved |
DOI: | 10.3233/CBM-130335 |
Published version: | http://dx.doi.org/10.3233/cbm-130335 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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