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Type: Journal article
Title: Performance of serum lipocalin 2 as a diagnostic marker for colorectal cancer
Author: Fung, K.
Priebe, I.
Purins, L.
Tabor, B.
Brierley, G.
Lockett, T.
Nice, E.
Gibbs, P.
Tie, J.
McMurrick, P.
Moore, J.
Ruszkiewicz, A.
Burgess, A.
Cosgrove, L.
Citation: Cancer Biomarkers, 2013; 13(2):75-79
Publisher: IOS Press
Issue Date: 2013
ISSN: 1574-0153
Statement of
Kim Y.C. Fung, Ilka Priebe, Leanne Purins, Bruce Tabor, Gemma V. Brierley, Trevor Lockett, Edouard Nice, Peter Gibbs, Jeannie Tie, Paul McMurrick, James Moore, Andrew Ruszkiewicz , Antony Burgess and Leah J. Cosgrove
Abstract: Background: Lipocalin 2 has been implicated in colorectal tumorigenesis but its usefulness as a diagnostic marker for the disease has previously never been determined. Methods: We have used ELISA immunoassay to measure the level of serum lipocalin 2 in a cohort consisting of colorectal cancer patients (n=196) and age/gender matched controls (n=99). Results: The median concentration of lipocalin 2 was found to be significantly higher (p< 0.0001) in the patient group (105.9 ng/mL, range 10.8-444.7 ng/mL) when compared to the control subjects (86.4 ng/mL, range 17.1-190.0 ng/mL). Additionally, no significant difference was observed between disease stage (Dukes' or T stage) in the patient cohort. Receiver operating characteristic analysis was performed to determine its performance as a diagnostic marker. The area under the curve was found to be 0.641 (95% confidence interval 0.576-0.706). Furthermore, the sensitivity of lipocalin 2 was found to be 24% at 90% specificity. Conclusions: Our study indicates that lipocalin 2 is not a suitable serum biomarker for the diagnosis of CRC.
Keywords: Colorectal cancer; biomarker; blood; diagnosis; lipocalin 2
Rights: © 2013 – IOS Press and the authors. All rights reserved
DOI: 10.3233/CBM-130335
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