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https://hdl.handle.net/2440/112385
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Type: | Journal article |
Title: | Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein |
Author: | Finnie, J. Manavis, J. |
Citation: | Journal of Veterinary Diagnostic Investigation, 2017; 29(6):852-855 |
Publisher: | SAGE Publications |
Issue Date: | 2017 |
ISSN: | 1040-6387 1943-4936 |
Statement of Responsibility: | John W. Finnie, Jim Manavis |
Abstract: | Neuroaxonal dystrophy (NAD) is a neurologic disorder of sheep characterized by accumulation of numerous axonal swellings (spheroids) in specific regions of the brainstem and spinal cord. Disruption of axonal transport, which is driven in anterograde and retrograde directions by the molecular motors, kinesin and dynein, respectively, is believed to contribute to spheroid development. Accordingly, we examined spheroids in ovine NAD cases immunohistochemically for kinesin and dynein and found both motor proteins, with dynein more strongly expressed than kinesin. Further investigations of the kinesin and dynein content of axonal spheroids in NAD, and other neurodegenerative disorders of domestic animals, could assist in better understanding the pathogenesis of these diseases. |
Keywords: | Axonal dystrophies dynein kinesin sheep neuroaxonal dystrophy |
Rights: | © 2017 The Author(s) |
DOI: | 10.1177/1040638717721579 |
Published version: | http://dx.doi.org/10.1177/1040638717721579 |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 8 |
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