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Type: Journal article
Title: Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein
Author: Finnie, J.
Manavis, J.
Citation: Journal of Veterinary Diagnostic Investigation, 2017; 29(6):852-855
Publisher: SAGE Publications
Issue Date: 2017
ISSN: 1040-6387
Statement of
John W. Finnie, Jim Manavis
Abstract: Neuroaxonal dystrophy (NAD) is a neurologic disorder of sheep characterized by accumulation of numerous axonal swellings (spheroids) in specific regions of the brainstem and spinal cord. Disruption of axonal transport, which is driven in anterograde and retrograde directions by the molecular motors, kinesin and dynein, respectively, is believed to contribute to spheroid development. Accordingly, we examined spheroids in ovine NAD cases immunohistochemically for kinesin and dynein and found both motor proteins, with dynein more strongly expressed than kinesin. Further investigations of the kinesin and dynein content of axonal spheroids in NAD, and other neurodegenerative disorders of domestic animals, could assist in better understanding the pathogenesis of these diseases.
Keywords: Axonal dystrophies
neuroaxonal dystrophy
Rights: © 2017 The Author(s)
DOI: 10.1177/1040638717721579
Appears in Collections:Animal and Veterinary Sciences publications
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