Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112385
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dc.contributor.authorFinnie, J.en
dc.contributor.authorManavis, J.en
dc.date.issued2017en
dc.identifier.citationJournal of Veterinary Diagnostic Investigation, 2017; 29(6):852-855en
dc.identifier.issn1040-6387en
dc.identifier.issn1943-4936en
dc.identifier.urihttp://hdl.handle.net/2440/112385-
dc.description.abstractNeuroaxonal dystrophy (NAD) is a neurologic disorder of sheep characterized by accumulation of numerous axonal swellings (spheroids) in specific regions of the brainstem and spinal cord. Disruption of axonal transport, which is driven in anterograde and retrograde directions by the molecular motors, kinesin and dynein, respectively, is believed to contribute to spheroid development. Accordingly, we examined spheroids in ovine NAD cases immunohistochemically for kinesin and dynein and found both motor proteins, with dynein more strongly expressed than kinesin. Further investigations of the kinesin and dynein content of axonal spheroids in NAD, and other neurodegenerative disorders of domestic animals, could assist in better understanding the pathogenesis of these diseases.en
dc.description.statementofresponsibilityJohn W. Finnie, Jim Manavisen
dc.language.isoenen
dc.publisherSAGE Publicationsen
dc.rights© 2017 The Author(s)en
dc.subjectAxonal dystrophies; dynein; kinesin; sheep; neuroaxonal dystrophyen
dc.titleAxonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dyneinen
dc.typeJournal articleen
dc.identifier.rmid0030075437en
dc.identifier.doi10.1177/1040638717721579en
dc.identifier.pubid365566-
pubs.library.collectionAnimal and Veterinary Sciences publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Animal and Veterinary Sciences publications

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