Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112402
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Type: Journal article
Title: Blood pressure variability after catheter-based renal sympathetic denervation in patients with resistant hypertension
Author: Ewen, S.
Dörr, O.
Ukena, C.
Linz, D.
Cremers, B.
Laufs, U.
Hamm, C.
Nef, H.
Bauer, A.
Mancia, G.
Böhm, M.
Mahfoud, F.
Citation: Journal of Hypertension, 2015; 33(12):2512-2518
Publisher: Lippincott Williams & Wilkins
Issue Date: 2015
ISSN: 0263-6352
1473-5598
Statement of
Responsibility: 
Sebastian Ewena, Oliver Do, rrb, Christian Ukenaa, Dominik Linza, Bodo Cremersa, Ulrich Laufsa, Christian Hammb, Holger Nefb, Axel Bauerc, Giuseppe Manciad, Michael Böhma, and Felix Mahfoud
Abstract: Renal denervation (RDN) reduces sympathetic activity and blood pressure (BP) in patients with resistant hypertension. Increased 24-h BP variability is associated with adverse cardiovascular outcomes and related to sympathetic activation.This multicenter study investigated the effect of RDN on BP variability in 84 patients with uncontrolled hypertension (office systolic BP ≥140 mmHg) despite treatment with greater than three antihypertensive agents. BP variability was assessed by means of standard deviation, coefficient of variation (standard deviation/mean), and average real variability of 24-h ambulatory SBP at 3-month and 6-month follow-up. RDN significantly reduced office BP by 17/6 mmHg at 3-month and 19/7 mmHg at 6-month follow-up (P < 0.001 for all) and 24-h ambulatory BP by 9/5 mmHg (P < 0.001/P = 0.001) after 3 months and 12/7 mmHg (P < 0.001/P < 0.001) after 6 months. Standard deviation significantly decreased from 17.1 to 14.9 mmHg (P = 0.008) and 15.3 mmHg (P = 0.037), consistent with a reduction of coefficient of variation from 0.116 to 0.103 (P = 0.035) and 0.104 (P = 0.071) and average real variability from 12.3 to 10.9 (P = 0.029) and 11.0 (P = 0.054) after 3-month and 6-month, respectively. Interestingly, also BP nonresponders (change in office systolic BP < 10 mmHg after 6 months) showed a significant reduction of standard deviation after 3 months (P = 0.041, n = 26) and a borderline significant reduction at 6-month (P = 0.057, n = 28).RDN reduces office and ambulatory BP and BP variability in patients with resistant hypertension. Improvement in BP variability was also documented in patients characterized as office BP nonresponders after 6 months.
Keywords: Blood pressure variability; renal denervation; resistant hypertension; sympathetic nervous system
Rights: © 2015 Wolters Kluwer Health, Inc. All rights reserved.
RMID: 0030067342
DOI: 10.1097/HJH.0000000000000751
Appears in Collections:Medicine publications

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