Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112444
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Type: Journal article
Title: White matter lesions are associated with specific depressive symptom trajectories among incident depression and dementia populations: three-city Dijon MRI study
Author: Tully, P.
Debette, S.
Mazoyer, B.
Tzourio, C.
Citation: American Journal of Geriatric Psychiatry, 2017; 25(12):1311-1321
Publisher: Elsevier
Issue Date: 2017
ISSN: 1064-7481
1545-7214
Statement of
Responsibility: 
Phillip J. Tully, Stephanie Debette, Bernard Mazoyer, Christophe Tzourio
Abstract: Evidence is mixed as to whether periventricular or deep white matter hyperintensities (WMHs) increase the risk for depressive symptoms, partly because of heterogeneity in depression measurement, short follow-up, and confounding by prodromal dementia. The study objective was to evaluate WMH volume in relation to discrete depressive symptoms over 10 years, stratifying by incident depression and dementia.In this prospective longitudinal cohort study of a representative population sample from Dijon, France, 1,440 participants aged 65-80 years (median age: 72 years; 59.5% women) without depression, dementia, or stroke at baseline were studied. Baseline T2-weighted images were obtained in a 1.5-T scanner to quantify WMHs (log cm3). Clinic visits were performed up to five times in a 10-year period to assess incident neurologic diseases and comorbidities. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression Scale and converted to factor z scores, representing somatic symptoms, depressed affect, low positive affect, and interpersonal problems.Periventricular WMH volume was uniquely associated with low positive affect among incident depression cases (β = 0.15; 95% confidence interval [CI]: 0.02-0.29; p = 0.026). Deep WMH volume was uniquely associated with depressed affect among incident dementia cases (β = 0.36; 95% CI: 0.05-0.68; p = 0.025). WMH volume (periventricular, deep, and total) was associated with interpersonal problems among persons who developed dementia with depression.The findings highlight that regional WMH volumes and specific depressive symptoms have clinical and prognostic relevance to help differentiate between persons at risk for depression and dementia.
Keywords: Depression; cerebrovascular disease; dementia; geriatric psychiatry; longitudinal; white matter hyperintensity
Rights: © 2017 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
RMID: 0030072767
DOI: 10.1016/j.jagp.2017.06.003
Appears in Collections:Public Health publications

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