Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112522
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dc.contributor.authorLee, C.en
dc.contributor.authorQin, J.en
dc.contributor.authorMunyard, K.en
dc.contributor.authorSiva Subramaniam, N.en
dc.contributor.authorWetherall, J.en
dc.contributor.authorStear, M.en
dc.contributor.authorGroth, D.en
dc.date.issued2012en
dc.identifier.citationAnimal Genetics, 2012; 43(4):429-437en
dc.identifier.issn0268-9146en
dc.identifier.issn1365-2052en
dc.identifier.urihttp://hdl.handle.net/2440/112522-
dc.description.abstractThis report describes single-nucleotide polymorphisms (SNPs) in the sheep major histocompatibility complex (MHC) class II and class III regions and provides insights into the internal structure of this important genomic complex. MHC haplotypes were deduced from sheep family trios based on genotypes from 20 novel SNPs representative of the class II region and 10 previously described SNPs spanning the class III region. All 30 SNPs exhibited Hardy-Weinberg proportions in the sheep population studied. Recombination within an extended sire haplotype was observed within the class II region for 4 of 20 sheep chromosomes, thereby supporting the presence of separated IIa and IIb subregions similar to those present in cattle. SNP heterozygosity varied across the class II and III regions. One segment of the class IIa subregion manifested very low heterozygosity for several SNPs spanning approximately 120 Kbp. This feature corresponds to a subregion within the human MHC class II region previously described as a 'SNP desert' because of its paucity of SNPs. Linkage disequilibrium (LD) was reduced at the junction separating the putative class IIb and IIa subregions and also between the class IIa and the class III subregions. The latter observation is consistent with either an unmapped physical separation at this location or more likely a boundary characterized by more frequent recombination between two conserved subregions, each manifesting high within-block LD. These results identify internal blocks of loci in the sheep MHC, within which recombination is relatively rare.en
dc.description.statementofresponsibilityC.Y. Lee, J. Qin, K.A. Munyard, N. Siva Subramaniam, J.D. Wetherall, M.J. Stear and D.M. Grothen
dc.language.isoenen
dc.publisherWileyen
dc.rights© 2011 The Authors, Animal Genetics © 2011 Stichting International Foundation for Animal Geneticsen
dc.subjectClass II; class III; linkage disequilibrium; sheep major histocompatibility complex; single-nucleotide polymorphismen
dc.titleConserved haplotype blocks within the sheep MHC and low SNP heterozygosity in the class IIa subregionen
dc.typeJournal articleen
dc.identifier.rmid0030049994en
dc.identifier.doi10.1111/j.1365-2052.2011.02268.xen
dc.identifier.pubid251423-
pubs.library.collectionAnimal and Veterinary Sciences publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidSiva Subramaniam, N. [0000-0002-4911-1997]en
Appears in Collections:Animal and Veterinary Sciences publications

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