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Type: Journal article
Title: Caspase-2 and the oxidative stress response
Author: Shalini, S.
Kumar, S.
Citation: Molecular & Cellular Oncology, 2015; 2(4):e1004956-1-e1004956-3
Publisher: Taylor & Francis
Issue Date: 2015
ISSN: 2372-3556
Statement of
Sonia Shalini and Sharad Kumar
Abstract: Caspase-2, one of the earliest discovered caspases, has emerged as a multifunctional enzyme with roles that are not limited to cell death. It acts as a tumor suppressor, prevents genetic instability, and protects against aging by playing a crucial role in sensing alterations in cellular redox status and activating the antioxidant defense system. These apparent non-apoptotic functions, only discovered recently, emphasize the importance of this often-neglected protease.
Keywords: Aging; apoptosis; caspase; oxidative stress; reactive oxygen species
Rights: © Sonia Shalini and Sharad Kumar This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
RMID: 0030051056
DOI: 10.1080/23723556.2015.1004956
Grant ID:
Appears in Collections:Medicine publications

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