Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112610
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Type: Journal article
Title: White matter connectivity disruptions in early and chronic schizophrenia
Author: Di Biase, M.
Cropley, V.
Baune, B.
Olver, J.
Amminger, G.
Phassouliotis, C.
Bousman, C.
McGorry, P.
Everall, I.
Pantelis, C.
Zalesky, A.
Citation: Psychological Medicine, 2017; 47(16):2797-2810
Publisher: Cambridge University Press
Issue Date: 2017
ISSN: 0033-2917
1469-8978
Statement of
Responsibility: 
M. A. Di Biase, V. L. Cropley, B. T. Baune, J. Olver, G. P. Amminger, C. Phassouliotis, C. Bousman, P. D. McGorry, I. Everall, C. Pantelis and A. Zalesky
Abstract: Background: White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalities differ between illness stages. We mapped the connectome in patients with recently diagnosed and chronic schizophrenia and investigated the extent and overlap of white matter connectivity disruptions between these illness stages. Methods: Diffusion-weighted magnetic resonance images were acquired in recent-onset (n = 19) and chronic patients (n = 45) with schizophrenia, as well as age-matched controls (n = 87). Whole-brain fiber tracking was performed to quantify the strength of white matter connections. Connections were tested for significant streamline count reductions in recent-onset and chronic groups, relative to separate age-matched controls. Permutation tests were used to assess whether disrupted connections significantly overlapped between chronic and recent-onset patients. Linear regression was performed to test whether connectivity was strongest in controls, weakest in chronic patients, and midway between these extremities in recent-onset patients (controls > recent-onset > chronic). Results: Compared with controls, chronic patients displayed a widespread network of connectivity disruptions (p < 0.01). In contrast, connectivity reductions were circumscribed to the anterior fibers of the corpus callosum in recent-onset patients (p < 0.01). A significant proportion of disrupted connections in recent-onset patients (86%) coincided with disrupted connections in chronic patients (p < 0.01). Linear regression revealed that chronic patients displayed reduced connectivity relative to controls, while recent-onset patients showed an intermediate reduction compared with chronic patients (p < 0.01). Conclusions: Connectome pathology in recent-onset patients with schizophrenia is confined to select tracts within a more extensive network of white matter connectivity disruptions found in chronic illness. These findings may suggest a trajectory of progressive deterioration of connectivity in schizophrenia.
Keywords: Schizophrenia; chronic; diffusion; first-episode; recent-onset; tractography
Rights: © Cambridge University Press 2017
RMID: 0030070909
DOI: 10.1017/S0033291717001313
Grant ID: http://purl.org/au-research/grants/nhmrc/1065742
http://purl.org/au-research/grants/nhmrc/628386
http://purl.org/au-research/grants/nhmrc/1105825
http://purl.org/au-research/grants/nhmrc/628880
http://purl.org/au-research/grants/nhmrc/1047648
Appears in Collections:Psychology publications

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