Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112627
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Type: Journal article
Title: 25-hydroxyvitamin D concentrations in children with Crohn's disease supplemented with either 2000 or 400 IU daily for 6 months: a randomized controlled study
Author: Wingate, K.
Jacobson, K.
Issenman, R.
Carroll, M.
Barker, C.
Israel, D.
Brill, H.
Weiler, H.
Barr, S.
Li, W.
Lyon, M.
Green, T.
Citation: Journal of Pediatrics, 2014; 164(4):860-865
Publisher: Mosby
Issue Date: 2014
ISSN: 0022-3476
1097-6833
Statement of
Responsibility: 
Kirstin E. Wingate, Kevan Jacobson, Robert Issenman, Matthew Carroll, Collin Barker, David Israel, Herbert Brill, Hope Weiler, Susan I. Barr, Wangyang Li, Michael R. Lyon and Timothy J. Green
Abstract: OBJECTIVES: To assess vitamin D status of pediatric patients with Crohn's disease (CD) and to compare their serum 25-hydroxyvitamin D (s-25OHD) with established cutoffs and assess whether 6 months of supplementation with 2000 IU/d, vs 400 IU/d, would reduce the group prevalence of vitamin D below these cutoffs. STUDY DESIGN: Subjects 8-18 years (n = 83) with quiescent CD were randomized to either 400 or 2000 IU vitamin D3/d for 6 months. RESULTS: Baseline mean ± SD s-25OHD was 24 ± 8 ng/mL; 13 subjects (16%) had an s-25OHD <16 ng/mL, 27 (33%) < 20 ng/mL, and 65 (79%) < 30 ng/mL. There was no significant difference between groups in achieving the cutoffs of 16 ng/mL or 20 ng/mL at 6 months; however, only 35% of the 400 IU group achieved the greater cutoff of 30 ng/mL compared with 74% in the 2000 IU group (P < .001). Baseline adjusted mean s-25OHD concentrations at 6 months were 9.6 ng/mL (95% CI 6.0-13.2, P < .001) greater in the 2000 IU than the 400 IU group. Disease activity was not affected by supplement dose. Few subjects exceeded safety marker cutoffs, and this did not differ by dose. CONCLUSIONS: At baseline, a high proportion of patients had a mean s-25OHD >20 ng/mL. 2000 IU vitamin D3/d is more effective in raising s-25OHD concentrations to > 30 ng/mL in children with CD than 400 IU/d, but both treatments were equally effective at achieving 16 or 20 ng/mL.
Keywords: CD; Crohn's disease; CV%; coefficient of variation; ESR; erythrocyte sedimentation rate; FFQ; Food Frequency Questionnaire; ITT; intent to treat; PCDAI; pediatric Crohn's disease activity index; RDA; recommended dietary allowance; s-25OHD; serum 25-hydroxyvitamin D
Rights: © 2014 Mosby Inc.
RMID: 0030087134
DOI: 10.1016/j.jpeds.2013.11.071
Appears in Collections:Paediatrics publications

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