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Type: Journal article
Title: Carbon nanotubes altering specificity of repeated PCR and DNA integrity properties
Author: Du, X.
An, H.
Jin, B.
Meng, L.
Liu, Q.
Citation: Journal of Nanoscience and Nanotechnology, 2014; 14(7):5547-5551
Publisher: American Scientific Publishers
Issue Date: 2014
ISSN: 1533-4880
Statement of
Xiongwei Du, Hongjie An, Bo Jin, Liangyu Meng, Qingdai Liu
Abstract: We have investigated the impact of aqueous suspension of single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) on performance of repeated PCR, and discussed their thermal impact on DNA characteristics. Both SWCNTs and MWCNTs are found significantly enhancing the specificity of the repeated PCR and capable of inhibition of long DNA thermal degradation. SWCNTs performed a better specificity in repeated PCR than MWCNTs did. MWCNT-DNA binding was more favorable for protecting long DNA from thermal degradation than SWCNT-DNA binding. The results suggested that CNTs are very useful in repeated PCR working on limited amount of DNA resources.
Keywords: Sensitivity and Specificity
Rights: Copyright status unknown
RMID: 0030009489
DOI: 10.1166/jnn.2014.8874
Appears in Collections:Chemical Engineering publications

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