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Type: Journal article
Title: Changes in neural connectivity and memory following a yoga intervention for older adults: a pilot study
Author: Eyre, H.
Acevedo, B.
Yang, H.
Siddarth, P.
Van Dyk, K.
Ercoli, L.
Leaver, A.
Cyr, N.
Narr, K.
Baune, B.
Khalsa, D.
Lavretsky, H.
Citation: Journal of Alzheimer's Disease, 2016; 52(2):673-684
Publisher: IOS Press
Issue Date: 2016
ISSN: 1387-2877
Statement of
Harris A. Eyre, Bianca Acevedo, Hongyu Yang, Prabha Siddarth, Kathleen Van Dyk, Linda Ercoli, Amber M. Leaver, Natalie St. Cyr, Katherine Narr, Bernhard T. Baune, Dharma S. Khalsa and Helen Lavretsky
Abstract: Background: No study has explored the effect of yoga on cognitive decline and resting-state functional connectivity. Objectives: This study explored the relationship between performance on memory tests and resting-state functional connectivity before and after a yoga intervention versus active control for subjects with mild cognitive impairment (MCI). Methods: Participants ( ≥ 55 y) with MCI were randomized to receive a yoga intervention or active “gold-standard” control (i.e., memory enhancement training (MET)) for 12 weeks. Resting-state functional magnetic resonance imaging was used to map correlations between brain networks and memory performance changes over time. Default mode networks (DMN), language and superior parietal networks were chosen as networks of interest to analyze the association with changes in verbal and visuospatial memory performance. Results: Fourteen yoga and 11 MET participants completed the study. The yoga group demonstrated a statistically significant improvement in depression and visuospatial memory. We observed improved verbal memory performance correlated with increased connectivity between the DMN and frontal medial cortex, pregenual anterior cingulate cortex, right middle frontal cortex, posterior cingulate cortex, and left lateral occipital cortex. Improved verbal memory performance positively correlated with increased connectivity between the language processing network and the left inferior frontal gyrus. Improved visuospatial memory performance correlated inversely with connectivity between the superior parietal network and the medial parietal cortex. Conclusion:Yoga may be as effective as MET in improving functional connectivity in relation to verbal memory performance. These findings should be confirmed in larger prospective studies.
Keywords: Brain
Neural Pathways
Magnetic Resonance Imaging
Pilot Projects
Neuropsychological Tests
Functional Neuroimaging
Cognitive Dysfunction
Rights: © 2016 – IOS Press and the authors. All rights reserved This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License.
DOI: 10.3233/JAD-150653
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