Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112773
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dc.contributor.authorJobling, A.en
dc.contributor.authorGuymer, R.en
dc.contributor.authorVessey, K.en
dc.contributor.authorGreferath, U.en
dc.contributor.authorMills, S.en
dc.contributor.authorBrassington, K.en
dc.contributor.authorLuu, C.en
dc.contributor.authorAung, K.en
dc.contributor.authorTrogrlic, L.en
dc.contributor.authorPlunkett, M.en
dc.contributor.authorFletcher, E.en
dc.date.issued2015en
dc.identifier.citationFASEB Journal, 2015; 29(2):696-710en
dc.identifier.issn0892-6638en
dc.identifier.issn1530-6860en
dc.identifier.urihttp://hdl.handle.net/2440/112773-
dc.description.abstractAge-related macular degeneration (AMD) is a leading cause of vision loss, characterized by drusen deposits and thickened Bruch's membrane (BM). This study details the capacity of nanosecond laser treatment to reduce drusen and thin BM while maintaining retinal structure. Fifty patients with AMD had a single nanosecond laser treatment session and after 2 yr, change in drusen area was compared with an untreated cohort of patients. The retinal effect of the laser was determined in human and mouse eyes using immunohistochemistry and compared with untreated eyes. In a mouse with thickened BM (ApoEnull), the effect of laser treatment was quantified using electron microscopy and quantitative PCR. In patients with AMD, nanosecond laser treatment reduced drusen load at 2 yr. Retinal structure was not compromised in human and mouse retina after laser treatment, with only a discrete retinal pigment epithelium (RPE) injury, and limited mononuclear cell response observed. BM was thinned in the ApoEnull mouse 3 mo after treatment (ApoEnull treated 683 ± 38 nm, ApoEnull untreated 890 ± 60 nm, C57Bl6J 606 ± 43 nm), with the expression of matrix metalloproteinase-2 and -3 increased (>260%). Nanosecond laser resolved drusen independent of retinal damage and improved BM structure, suggesting this treatment has the potential to reduce AMD progression.en
dc.description.statementofresponsibilityA.I. Jobling, R.H. Guymer, K.A. Vessey, U. Greferath, S.A. Mills, K.H. Brassington, C.D. Luu, K.Z. Aung, L. Trogrlic, M. Plunkett and E.L. Fletcheren
dc.language.isoenen
dc.publisherFederation of American Societies for Experimental Biologyen
dc.rights© FASEBen
dc.subjectVision loss; drusen; Bruch’s membrane; matrix metalloproteinaseen
dc.titleNanosecond laser therapy reverses pathologic and molecular changes in age-related macular degeneration without retinal damageen
dc.typeJournal articleen
dc.identifier.rmid0030090232en
dc.identifier.doi10.1096/fj.14-262444en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1038220en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1061418en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1061419en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/529905en
dc.identifier.pubid176437-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medicine publications

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