Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112791
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Type: Journal article
Title: Nanosecond-laser application in intermediate AMD: 12-month results of fundus appearance and macular function
Author: Guymer, R.
Brassington, K.
Dimitrov, P.
Makeyeva, G.
Plunkett, M.
Xia, W.
Chauhan, D.
Vingrys, A.
Luu, C.
Citation: Clinical and Experimental Ophthalmology, 2014; 42(5):466-479
Publisher: Wiley
Issue Date: 2014
ISSN: 1442-6404
1442-9071
Statement of
Responsibility: 
Robyn H Guymer, Kate H Brassington, Peter Dimitrov, Galina Makeyeva, Malcolm Plunkett, Wie Xia, Devinder Chauhan, Algis Vingrys and Chi D Luu
Abstract: Background: A novel, ultra-low energy nanosecond laser (retinal rejuvenation therapy) has been developed with the aim to slow progression of early age-related macular degeneration (AMD). The safety, changes in fundus characteristics and macular function in a cohort of participants with bilateral intermediate AMD are reported. Design: Prospective non-randomised, pilot intervention study. Participants or Samples: Subjects with bilateral intermediate AMD (n = 50, aged 50-75 years). Methods: Ultra-low energy laser pulses applied in 12 spots around the macula of one eye (0.15-0.45 mJ), using 400 μm diameter spot, 3 nanosecond pulse length, 532 nm wavelength and energy titrated to each patient. Main Outcome Measures: Best corrected visual acuity, drusen area and macular sensitivity (flicker perimetry) at baseline and at 3, 6 and 12 months post-laser. Results: Treatment was painless with no clinically visible lesions. No participant developed choroidal neovascularization, while two with thin central retinal thickness at baseline developed atrophy at 12-month follow up. Drusen area was reduced in 44% of treated eyes and 22% of untreated fellow eyes, with changes in drusen and function not being coincident. Improvement in flicker threshold within the central 3° was observed in both the treated and untreated fellow eyes at 3 months post-laser. Of the 11 eyes at greatest risk of progression (flicker defect >15 dB), seven improved sufficiently to be taken out of this high-risk category. Conclusions: A single unilateral application of nanosecond laser to the macula produced bilateral improvements in macula appearance and function. The nanosecond retinal rejuvenation therapy laser warrants ongoing evaluation as an early intervention for AMD.
Keywords: AMD; macula; nanosecond laser; perimetry
Rights: © 2013 Royal Australian and New Zealand College of Ophthalmologists
RMID: 0030090235
DOI: 10.1111/ceo.12247
Grant ID: http://purl.org/au-research/grants/nhmrc/529905
http://purl.org/au-research/grants/nhmrc/529923
Appears in Collections:Medicine publications

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