Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112799
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dc.contributor.authorMoran, L.en
dc.contributor.authorMundra, P.en
dc.contributor.authorTeede, H.en
dc.contributor.authorMeikle, P.en
dc.date.issued2017en
dc.identifier.citationJournal of Molecular Endocrinology, 2017; 59(1):93-104en
dc.identifier.issn0952-5041en
dc.identifier.issn1479-6813en
dc.identifier.urihttp://hdl.handle.net/2440/112799-
dc.description.abstractPolycystic ovary syndrome (PCOS) affects up to 18% of reproductive-aged women with reproductive and metabolic complications. While lipidomics can identify associations between lipid species and metabolic diseases, no research has examined the association of lipid species with the pathophysiological features of PCOS. The aim of this study was to examine the lipidomic profile in women with and without PCOS. This study was a cross-sectional study in 156 age-matched pre-menopausal women (18-45 years, BMI >20 kg/m2; n = 92 with PCOS, n = 64 without PCOS). Outcomes included the association between the plasma lipidomic profile (325 lipid species (24 classes) using liquid chromatography mass spectrometry) and PCOS, adiposity, homeostasis assessment of insulin resistance (HOMA), sex hormone-binding globulin (SHBG) and free androgen index (FAI). There were no associations of the lipidomic profile with PCOS or testosterone. HOMA was positively associated with 2 classes (dihydroceramide and triacylglycerol), SHBG was inversely associated with 2 classes (diacylglycerol and triacylglycerol), FAI was positively associated with 8 classes (ceramide, phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, lysophosphatidylethanolamine, phosphatidylinositol, diacylglycerol and triacylglycerol) and waist circumference was associated with 8 classes (4 positively (dihydroceramide, phosphatidylglycerol, diacylglycerol and triacylglycerol) and 4 inversely (trihexosylceramide, GM3 ganglioside, alkenylphosphatidylcholine and alkylphosphatidylethanolamine)). The lipidomic profile was primarily related to central adiposity and FAI in women with or without PCOS. This supports prior findings that adiposity is a key driver of dyslipidaemia in PCOS and highlights the need for weight management through lifestyle interventions.en
dc.description.statementofresponsibilityL J Moran, P A Mundra, H J Teede and P J Meikleen
dc.language.isoenen
dc.publisherSociety for Endocrinologyen
dc.rights© 2017 Society for Endocrinologyen
dc.subjectPolycystic ovary syndrome; lipidomics; obesity; hyperandrogenism; insulin resistanceen
dc.titleThe association of the lipidomic profile with features of polycystic ovary syndromeen
dc.typeJournal articleen
dc.identifier.rmid0030090224en
dc.identifier.doi10.1530/JME-17-0023en
dc.identifier.pubid397156-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidMoran, L. [0000-0001-5772-6484]en
dc.identifier.orcidTeede, H. [0000-0001-7609-577X]en
Appears in Collections:Obstetrics and Gynaecology publications

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