Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112806
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dc.contributor.authorSmith, C.en
dc.contributor.authorde lacey, S.en
dc.contributor.authorChapman, M.en
dc.contributor.authorRatcliffe, J.en
dc.contributor.authorNorman, R.en
dc.contributor.authorJohnson, N.en
dc.contributor.authorBoothroyd, C.en
dc.contributor.authorFahey, P.en
dc.date.issued2018en
dc.identifier.citationJAMA-Journal of the American Medical Association, 2018; 319(19):1990-1998en
dc.identifier.issn0098-7484en
dc.identifier.issn1538-3598en
dc.identifier.urihttp://hdl.handle.net/2440/112806-
dc.description.abstractImportance: Acupuncture is widely used by women undergoing in vitro fertilization (IVF), although the evidence for efficacy is conflicting. Objective: To determine the efficacy of acupuncture compared with a sham acupuncture control performed during IVF on live births. Design, Setting and Participants: A single-blind, parallel-group randomized clinical trial including 848 women undergoing a fresh IVF cycle was conducted at 16 IVF centers in Australia and New Zealand between June 29, 2011, and October 23, 2015, with 10 months of pregnancy follow-up until August 2016. Interventions: Women received either acupuncture (n = 424) or a sham acupuncture control (n = 424). The first treatment was administered between days 6 to 8 of follicle stimulation, and 2 treatments were administered prior to and following embryo transfer. The sham control used a noninvasive needle placed away from the true acupuncture points. Main Outcomes and Measures: The primary outcome was live birth, defined as the delivery of 1 or more living infants at greater than 20 weeks' gestation or birth weight of at least 400 g. Results: Among 848 randomized women, 24 withdrew consent, 824 were included in the study (mean [SD] age, 35.4 [4.3] years); 371 [45.0%] had undergone more than 2 previous IVF cycles), 607 proceeded to an embryo transfer, and 809 (98.2%) had data available on live birth outcomes. Live births occurred among 74 of 405 women (18.3%) receiving acupuncture compared with 72 of 404 women (17.8%) receiving sham control (risk difference, 0.5% [95% CI, -4.9% to 5.8%]; relative risk, 1.02 [95% CI, 0.76 to 1.38]). Conclusions and Relevance: Among women undergoing IVF, administration of acupuncture vs sham acupuncture at the time of ovarian stimulation and embryo transfer resulted in no significant difference in live birth rates. These findings do not support the use of acupuncture to improve the rate of live births among women undergoing IVF.en
dc.description.statementofresponsibilityCaroline A. Smith, Sheryl de Lacey, Michael Chapman, Julie Ratcliffe, Robert J. Norman, Neil P. Johnson, Clare Boothroyd, Paul Faheyen
dc.language.isoenen
dc.publisherAmerican Medical Associationen
dc.rights© 2018 American Medical Association. All rights reserved.en
dc.subjectHumans; Acupuncture Therapy; Embryo Transfer; Fertilization in Vitro; Ovulation Induction; Pregnancy Rate; Single-Blind Method; Pregnancy; Adult; Female; Live Birthen
dc.titleEffect of acupuncture vs sham acupuncture on live births among women undergoing in vitro fertilization: a randomized clinical trialen
dc.typeJournal articleen
dc.identifier.rmid0030089879en
dc.identifier.doi10.1001/jama.2018.5336en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1003661en
dc.identifier.pubid422044-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidRatcliffe, J. [0000-0001-7365-1988]en
dc.identifier.orcidNorman, R. [0000-0002-3118-3896]en
Appears in Collections:Obstetrics and Gynaecology publications

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