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dc.contributor.authorStewart, S.en
dc.contributor.authorChan, Y.en
dc.contributor.authorWong, C.en
dc.contributor.authorJennings, G.en
dc.contributor.authorScuffham, P.en
dc.contributor.authorEsterman, A.en
dc.contributor.authorCarrington, M.en
dc.identifier.citationEuropean Journal of Heart Failure, 2015; 17(6):620-630en
dc.description.abstractAims: The aim of this study was to determine the effectiveness of a long-term, nurse-led, multidisciplinary programme of home/clinic visits in preventing progressive cardiac dysfunction in individuals at risk of developing de novo chronic heart failure (CHF). Methods and Results: A pragmatic, single-centre (tertiary-referral hospital with specialist cardiological services), open-label, randomized controlled trial with blinded endpoint adjudication was carried out. In total, 624 cardiac inpatients (66 ± 11 years, 71% male, and 70% with CAD) were randomly allocated (1:1) to standard care or the study intervention. The intention-to-treat cohort comprised 310 standard care and 301 intervention participants. During 51.0 ± 8.2 months follow-up, 38/310 (12%) standard care [mean event-free survival 1865 days, 95% confidence interval (CI) 1817-1913 days] vs. 41/301 (14%) intervention participants (1855 days, 95% CI 1804-1906 days) experienced the primary composite endpoint of de novo CHF hospitalization or all-cause mortality (P = 0.574). Although there were no statistically significant differences in the rate of cardiovascular-related and emergency hospitalizations, the NIL-CHF (Nurse-led Intervention for Less Chronic Heart Failure) group accumulated 478 (0.214 ± 0.70 vs. 0.095 ± 0.284 days/participant/month; P = 0.052) and 1097 fewer days of hospital stay (0.391 ± 1.80 vs. 0.199 ± 0.47 days/participant/month; P = 0.023), respectively, compared with standard care. The intervention group also showed better cardiac recovery on echocardiography at 3 years [81/226 (35.8%) vs. 56/225 (24.9%), odds ratio 1.44, 95% CI 1.08-1.92, P = 0.011]. Conclusions: Relative to a high level of standard care, the NIL-CHF intervention was ineffective in preventing CHF and rehospitalization. On the other hand, it was associated with reduced hospital stay and improved cardiac function over the long term.en
dc.description.statementofresponsibilitySimon Stewart, Yih-Kai Chan, Chiew Wong, Garry Jennings, Paul Scuffham, Adrian Esterman, Melinda Carrington, and on behalf of the NIL-CHF Investigatorsen
dc.rights© 2015 The Authors. European Journal of Heart Failure © 2015 European Society of Cardiologyen
dc.subjectSecondary prevention; multidisciplinary care; nurse-led; cardiac dysfunctionen
dc.titleImpact of a nurse-led home and clinic-based secondary prevention programme to prevent progressive cardiac dysfunction in high-risk individuals: the Nurse-led Intervention for Less Chronic Heart Failure (NIL-CHF) randomized controlled studyen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidStewart, S. [0000-0001-9032-8998]en
dc.identifier.orcidEsterman, A. [0000-0001-7324-9171]en
Appears in Collections:Medicine publications

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