Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/112871
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dc.contributor.author | Ball, J. | - |
dc.contributor.author | Carrington, M. | - |
dc.contributor.author | Wood, K. | - |
dc.contributor.author | Stewart, S. | - |
dc.contributor.editor | Ai, X. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | PLoS One, 2013; 8(5):e65795-1-e65795-9 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2440/112871 | - |
dc.description.abstract | BACKGROUND: Gender-based clinical differences are increasingly being identified as having significant influence on the outcomes of patients with cardiovascular disease (CVD), including atrial fibrillation (AF). OBJECTIVE: To perform detailed clinical phenotyping on a cohort of hospitalised patients with chronic forms of AF to understand if gender-based differences exist in the clinical presentation, thrombo-embolic risk and therapeutic management of high risk patients hospitalised with chronic AF. METHODS: We are undertaking the Standard versus Atrial Fibrillation spEcific managemenT studY (SAFETY) - a multi-centre, randomised controlled trial of an AF-specific management intervention versus usual care. Extensive baseline profiling of recruited patients was undertaken to identify gender-specific differences for risk delineation. RESULTS: We screened 2,438 patients with AF and recruited 335 into SAFETY. Of these, 48.1% were women who were, on average, 5 years older than their male counterparts. Women and men displayed divergent antecedent profiles, with women having a higher thrombo-embolic risk but being prescribed similar treatment regimens. More women than men presented to hospital with co-morbid thyroid dysfunction, depression, renal impairment and obesity. In contrast, more men presented with coronary artery disease (CAD) and/or chronic obstructive pulmonary disease (COPD). Even when data was age-adjusted, women were more likely to live alone (odds ratio [OR] 2.33; 95% confidence interval [CI] 1.47 to 3.69), have non-tertiary education (OR 2.69; 95% CI 1.61 to 4.48) and be symptomatic (OR 1.93; 95% CI 1.06 to 3.52). CONCLUSION: Health care providers should be cognisant of gender-specific differences in an attempt to individualise and, hence, optimise the management of patients with chronic AF and reduce potential morbidity and mortality. | - |
dc.description.statementofresponsibility | Jocasta Ball, Melinda J. Carrington, Kathryn A. Wood, Simon Stewart (the SAFETY Investigators) | - |
dc.language.iso | en | - |
dc.publisher | Public Library Science | - |
dc.rights | © 2013 Ball et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | - |
dc.source.uri | http://dx.doi.org/10.1371/journal.pone.0065795 | - |
dc.subject | Atrial fibrillation; cardiovascular diseases; patients; safety studies; chronic obstructive pulmonary disease; cardiovascular diseases in women; coronary heart disease; health services research | - |
dc.title | Women versus men with chronic atrial fibrillation: insights from the Standard versus Atrial Fibrillation spEcific managemenT studY (SAFETY) | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1371/journal.pone.0065795 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/519823 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Stewart, S. [0000-0001-9032-8998] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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hdl_112871.pdf | Published Version | 757.57 kB | Adobe PDF | View/Open |
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