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Type: Journal article
Title: Peri-prostatic adipose tissue: the metabolic microenvironment of prostate cancer
Author: Nassar, Z.
Aref, A.
Miladinovic, D.
Mah, C.
Raj, G.
Hoy, A.
Butler, L.
Citation: BJU International, 2018; 121(Suppl. 3):9-21
Publisher: Wiley-Blackwell
Issue Date: 2018
ISSN: 1464-4096
Statement of
Zeyad D. Nassar, Adel T. Aref, Dushan Miladinovic, Chui Yan Mah, Ganesh V. Raj, Andrew J. Hoy and Lisa M. Butler
Abstract: Emerging data have linked certain features of clinical prostate cancer (PCa) to obesity and, more specifically, increased adiposity. Whereas the large number of clinical studies and meta-analyses that have explored the associations between PCa and obesity have shown considerable variability, particularly in relation to prostate cancer risk, there is an accumulating weight of evidence consistently linking obesity to greater aggressiveness of disease. In probing this association mechanistically, it has been posited that peri-prostatic adipose tissue (PPAT), a significant component of the prostate microenvironment, may be a critical source of fatty acids and other mitogens and thereby influences PCa pathogenesis and progression. Notably, several recent studies have identified secreted factors from both PPAT and PCa that potentially mediate the two-way communication between these intimately linked tissues. In the present review, we summarize the available literature regarding the relationship between PPAT and PCa, including the potential biological mediators of that relationship, and explore emerging areas of interest for future research endeavours.
Keywords: adipocytes; obesity; peri-prostatic adipose tissue; prostate cancer; tumour microenvironment
Rights: © 2018 The Authors. BJU International © 2018 BJU International. Published by John Wiley & Sons Ltd.
RMID: 0030082448
DOI: 10.1111/bju.14173
Grant ID:
Appears in Collections:Medicine publications

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