Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/113165
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dc.contributor.author | Dulhunty, J. | - |
dc.contributor.author | Roberts, J. | - |
dc.contributor.author | Davis, J. | - |
dc.contributor.author | Webb, S. | - |
dc.contributor.author | Bellomo, R. | - |
dc.contributor.author | Gomersall, C. | - |
dc.contributor.author | Shirwadkar, C. | - |
dc.contributor.author | Eastwood, G. | - |
dc.contributor.author | Myburgh, J. | - |
dc.contributor.author | Paterson, D. | - |
dc.contributor.author | Starr, T. | - |
dc.contributor.author | Paul, S. | - |
dc.contributor.author | Lipman, J. | - |
dc.contributor.author | Peck, L. | - |
dc.contributor.author | Young, H. | - |
dc.contributor.author | Boschert, C. | - |
dc.contributor.author | Fletcher, J. | - |
dc.contributor.author | Smith, J. | - |
dc.contributor.author | Nand, K. | - |
dc.contributor.author | Sara, T. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | American Journal of Respiratory and Critical Care Medicine, 2015; 192(11):1298-1305 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.issn | 1535-4970 | - |
dc.identifier.uri | http://hdl.handle.net/2440/113165 | - |
dc.description.abstract | Rationale: Continuous infusion of β-lactam antibiotics may improve outcomes because of time-dependent antibacterial activity compared with intermittent dosing. Objectives: To evaluate the efficacy of continuous versus intermittent infusion in patients with severe sepsis. Methods: We conducted a randomized controlled trial in 25 intensive care units (ICUs). Participants commenced on piperacillin–tazobactam, ticarcillin–clavulanate, or meropenem were randomized to receive the prescribed antibiotic via continuous or 30-minute intermittent infusion for the remainder of the treatment course or until ICU discharge. The primary outcome was the number of alive ICU-free days at Day 28. Secondary outcomes were 90-day survival, clinical cure 14 days post antibiotic cessation, alive organ failure–free days at Day 14, and duration of bacteremia. Measurements and Main Results: We enrolled 432 eligible participants with a median age of 64 years and an Acute Physiology and Chronic Health Evaluation II score of 20. There was no difference in ICU-free days: 18 days (interquartile range, 2–24) and 20 days (interquartile range, 3–24) in the continuous and intermittent groups (P = 0.38). There was no difference in 90-day survival: 74.3% (156 of 210) and 72.5% (158 of 218); hazard ratio, 0.91 (95% confidence interval, 0.63–1.31; P = 0.61). Clinical cure was 52.4% (111 of 212) and 49.5% (109 of 220); odds ratio, 1.12 (95% confidence interval, 0.77–1.63; P = 0.56). There was no difference in organ failure–free days (6 d; P = 0.27) and duration of bacteremia (0 d; P = 0.24). Conclusions: In critically ill patients with severe sepsis, there was no difference in outcomes between β-lactam antibiotic administration by continuous and intermittent infusion. | - |
dc.description.statementofresponsibility | Joel M. Dulhunty, Jason A. Roberts, Joshua S. Davis, Steven A. R. Webb, Rinaldo Bellomo ... Milind Sanap ... et al. | - |
dc.language.iso | en | - |
dc.publisher | ATS Journals | - |
dc.rights | © 2015 by the American Thoracic Society | - |
dc.source.uri | http://dx.doi.org/10.1164/rccm.201505-0857oc | - |
dc.subject | BLING II Investigators for the ANZICS Clinical Trials Group * | - |
dc.subject | Humans | - |
dc.subject | Sepsis | - |
dc.subject | beta-Lactams | - |
dc.subject | Anti-Bacterial Agents | - |
dc.subject | Treatment Outcome | - |
dc.subject | Length of Stay | - |
dc.subject | Infusions, Intravenous | - |
dc.subject | Drug Administration Schedule | - |
dc.subject | Survival Analysis | - |
dc.subject | Prospective Studies | - |
dc.subject | Double-Blind Method | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | A multicenter randomized trial of continuous versus intermittent β-lactam infusion in severe sepsis | - |
dc.title.alternative | A multicenter randomized trial of continuous versus intermittent beta-lactam infusion in severe sepsis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1164/rccm.201505-0857OC | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1013411 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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