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https://hdl.handle.net/2440/113206
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dc.contributor.author | Tavella, R. | - |
dc.contributor.author | Cutri, N. | - |
dc.contributor.author | Tucker, G. | - |
dc.contributor.author | Adams, R. | - |
dc.contributor.author | Spertus, J. | - |
dc.contributor.author | Beltrame, J.F. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | European Heart Journal - Quality of Care and Clinical Outcomes, 2016; 2(2):117-124 | - |
dc.identifier.issn | 2058-5225 | - |
dc.identifier.issn | 2058-1742 | - |
dc.identifier.uri | http://hdl.handle.net/2440/113206 | - |
dc.description.abstract | Aims: Approximately 30% of patients undergoing coronary angiography for chest pain have insignificant coronary artery disease (ICAD). The subsequent health status of these patients is largely unknown. The current study was a cross-sectional, longitudinal comparison of health status outcomes 12 months following angiography, in a cohort of patients with stable chest pain and ICAD to: (i) patients with significant coronary artery disease (CAD) and (ii) a healthy control cohort. Methods and Results: Patients undergoing elective angiography for chest pain were recruited and classified as CAD (coronary stenosis ≥50%) or ICAD. Clinical and health-related quality-of-life (HRQoL) data were collected at baseline, 1, 6, and 12 months following angiography. The 12-month health status was cross-sectionally compared with a healthy control group recruited from the same geographic zone. Among 758 patients undergoing coronary angiography, 253 (33%) had ICAD. Insignificant coronary artery disease patients were younger, more often female, and had less cardiac risk factors than CAD patients. At 12 months, 48% of ICAD and 59% of CAD patients were chest pain-free, and both groups had similar Short-Form 36 Physical Component Summary (PCS) scores (41 ± 11 vs. 41 ± 11 for ICAD and CAD patients, respectively, P > 0.05). However, at 12 months, both the ICAD and CAD patients had significantly lower PCS scores compared with healthy controls (41 ± 11 vs. 49 ± 11, P < 0.05 for both CAD and ICAD). Conclusion: Although ICAD patients are frequently considered 'normal' from a cardiac perspective, they often have residual chest pain and impaired HRQoL at 12 months. Novel strategies are needed to manage ICAD patients to improve health outcomes. | - |
dc.description.statementofresponsibility | Rosanna Tavella, Natalie Cutri, Graeme Tucker, Robert Adams, John Spertus and John F. Beltrame | - |
dc.language.iso | en | - |
dc.publisher | Oxford University Press | - |
dc.rights | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com. | - |
dc.source.uri | http://dx.doi.org/10.1093/ehjqcco/qcv034 | - |
dc.subject | Insignificant coronary artery disease; stable angina; angiography; health status; health outcomes; quality of life | - |
dc.title | Natural history of patients with insignificant coronary artery disease | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/ehjqcco/qcv034 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Tavella, R. [0000-0002-4869-465X] | - |
dc.identifier.orcid | Tucker, G. [0000-0003-2621-5942] | - |
dc.identifier.orcid | Adams, R. [0000-0002-7572-0796] | - |
dc.identifier.orcid | Spertus, J. [0000-0002-2839-2611] | - |
dc.identifier.orcid | Beltrame, J.F. [0000-0002-4294-6510] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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