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|Title:||Polyandric acid A, a clerodane diterpenoid from the Australian medicinal plant Dodonaea polyandra, attenuates pro-inflammatory cytokine secretion in vitro and in vivo|
|Citation:||Journal of Natural Products, 2014; 77(1):85-91|
|Publisher:||American Chemical Society|
|Bradley S. Simpson, Xianling Luo, Maurizio Costabile, Gillian E. Caughey, Jiping Wang, David J. Claudie, Ross A. McKinnon, and Susan J. Semple|
|Abstract:||Dodonaea polyandra is a medicinal plant used traditionally by the Kuuku I'yu (Northern Kaanju) indigenous people of Cape York Peninsula, Australia. The most potent of the diterpenoids previously identified from this plant, polyandric acid A (1), has been examined for inhibition of pro-inflammatory cytokine production and other inflammatory mediators using well-established acute and chronic mouse ear edema models and in vitro cellular models. Topical application of 1 significantly inhibited interleukin-1β production in mouse ear tissue in an acute model. In a chronic skin inflammation model, a marked reduction in ear thickness, associated with significant reduction in myeloperoxidase accumulation, was observed. Treatment of primary neonatal human keratinocytes with 1 followed by activation with phorbol ester/ionomycin showed a significant reduction in IL-6 secretion. The present study provides evidence that the anti-inflammatory properties of 1 are due to inhibition of pro-inflammatory cytokines associated with skin inflammation and may be useful in applications for skin inflammatory conditions including psoriasis and dermatitis.|
|Description:||Published: January 8, 2014|
|Rights:||© 2014 American Chemical Society and American Society of Pharmacognosy|
|Appears in Collections:||Pharmacology publications|
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