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dc.contributor.authorOdenthal, C.-
dc.contributor.authorSimpson, S.-
dc.contributor.authorOughton, J.-
dc.contributor.authorvan der Mei, I.-
dc.contributor.authorRose, S.-
dc.contributor.authorFripp, J.-
dc.contributor.authorLucas, R.-
dc.contributor.authorTaylor, B.-
dc.contributor.authorDear, K.-
dc.contributor.authorPonsonby, A.-
dc.contributor.authorCoulthard, A.-
dc.contributor.authorAusimmune AusLong Investigator Groups-
dc.contributor.authorChapman, C.-
dc.contributor.authorDwyer, T.-
dc.contributor.authorKilpatrick, T.-
dc.contributor.authorMcMichael, T.-
dc.contributor.authorPender, M.-
dc.contributor.authorValery, P.-
dc.contributor.authorWilliams, D.-
dc.contributor.authorBroadley, S.-
dc.contributor.authoret al.-
dc.identifier.citationJournal of Medical Imaging and Radiation Oncology, 2017; 61(4):453-460-
dc.description.abstractIntroduction: Patients presenting with clinically isolated syndrome (CIS) may proceed to clinically definite multiple sclerosis (CDMS). Midsagittal corpus callosum area (CCA) is a surrogate marker for callosal atrophy, and can be obtained from a standard MRI study. This study explores the relationship between CCA measured at CIS presentation (baseline) and at 5 years post presentation, with conversion from CIS to CDMS. The association between CCA and markers of disability progression is explored. Methods: Corpus callosum area was measured on MRI scans at presentation and 5-year review following diagnosis of a first demyelinating event, or evidence of progressive MS, in 143 participants in the Ausimmune/AusLong Study. Relationships between CCA (at baseline and follow-up) and clinical outcomes were assessed. Results: Mean CCA at baseline study was 6.63 cm² (SD 1.01). Patients who converted to MS by 5-year review (n = 100) had a significantly smaller mean CCA at follow-up (6.22 vs. 6.74, P = 0.007). Greater CCA reduction was associated with higher annualized relapse rate over follow-up. Conclusion: Baseline CCA obtained from standard MRI protocols may be compared with subsequent MRI examinations as a surrogate for neurodegeneration and cerebral atrophy in patients with MS. This study demonstrates an association between CCA and disability in individuals presenting with CIS who convert to MS.-
dc.description.statementofresponsibilityCara Odenthal, Steve Simpson Jr, Justin Oughton, Ingrid van der Mei, Stephen Rose, Jurgen Fripp, Robyn Lucas, Bruce Taylor, Keith Dear, Anne-Louise Ponsonby, Alan Coulthard, and the Ausimmune AusLong Investigator Groups-
dc.rights© 2016 The Royal Australian and New Zealand College of Radiologists-
dc.subjectAtrophy; clinically isolated syndrome; corpus callosum; magnetic resonance imaging; multiple sclerosis-
dc.titleMidsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: a multicentre Australian cohort study-
dc.typeJournal article-
dc.identifier.orcidDear, K. [0000-0002-0788-7404]-
Appears in Collections:Aurora harvest 8
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