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dc.contributor.authorJasieniak, M.en
dc.contributor.authorCoad, B.en
dc.contributor.authorGriesser, H.en
dc.identifier.citationBiointerphases, 2015; 10(4):04A310-1-04A310-11en
dc.description.abstractIn the development of bioactive coatings on biomaterials, it is essential to characterize the successful fabrication and the uniformity of intended coatings by sensitive surface analytical techniques, so as to ensure reliable interpretation of observed biointerfacial responses. This can, however, be challenging when small bioactive molecules are grafted onto biomaterials surfaces at sub- and near-monolayer densities. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) provides the required sensitivity, but ion signals from small grafted molecules may still be dominated by fragment ions from the underlying polymer. In such cases, multivariate analysis provides valuable enhancement of spectral data, as illustrated here by examples comprising the surface grafting of bioactive serrulatane molecules, the peptide GRGDSP, the oligonucleotide 15-thymidine, and the antifungal compound Amphotericin B. The authors also show how ToF-SIMS plus principal component analysis can distinguish between covalent grafting and physisorption of the antibiotics caspofungin and micafungin.en
dc.description.statementofresponsibilityMarek Jasieniak, Bryan R. Coad and Hans J. Griesseraen
dc.publisherAmerican Institute of Physicsen
dc.rights© 2015 American Vacuum Society.en
dc.subjectBiological Products; Coated Materials, Biocompatible; Spectrometry, Mass, Secondary Ion; Multivariate Analysis; Surface Propertiesen
dc.titleToF-SIMS multivariate analysis of surface-grafted small bioactive moleculesen
dc.typeJournal articleen
pubs.library.collectionChemistry and Physics publicationsen
dc.identifier.orcidCoad, B. [0000-0003-3297-3977]en
Appears in Collections:Chemical Engineering publications

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