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Type: Journal article
Title: Improved oxidation of aromatic and aliphatic hydrocarbons using rate enhancing variants of P450Bm3 in combination with decoy molecules
Author: Munday, S.
Shoji, O.
Watanabe, Y.
Wong, L.
Bell, S.
Citation: Chemical Communications, 2016; 52(5):1036-1039
Publisher: The Royal Society of Chemistry
Issue Date: 2016
ISSN: 1359-7345
Statement of
Samuel D. Munday, Osami Shoji, Yoshihito Watanabe, Luet-Lok Wong and Stephen G. Bell
Abstract: Enzyme performance can be improved using decoy molecules or engineered variants to accelerate the activity without affecting selectivity. Here we combine a rate accelerator variant of cytochrome P450Bm3 with decoy molecules to enhance the oxidation activity of a range of small organic molecules. This combined approach offers superior biocatalytic efficiency without modifying the product distribution.
Rights: This journal is © The Royal Society of Chemistry 2016
DOI: 10.1039/C5CC09247G
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