Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/113462
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Type: Journal article
Title: PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis
Author: Nassar, Z.
Moon, H.
Duong, T.
Neo, L.
Hill, M.
Francois, M.
Parton, R.
Parat, M.
Citation: Oncotarget, 2013; 4(10):1844-1855
Publisher: Impact Journals LLC
Issue Date: 2013
ISSN: 1949-2553
1949-2553
Statement of
Responsibility: 
Zeyad D. Nassar, Hyeongsun Moon, Tam Duong, LiQi Neo, Michelle M. Hill, Mathias Francois, Robert G. Parton, Marie-Odile Parat
Abstract: Caveolae are specialized plasma membrane subdomains implicated in cellular functions such as migration, signalling and trafficking. Caveolin-1 and polymerase I and transcript release factor (PTRF)/cavin-1 are essential for caveola formation. Caveolin-1 is overexpressed and secreted in prostate tumors and promotes aggressiveness and angiogenesis. In contrast, a lack of PTRF expression is reported in prostate cancer, and ectopic PTRF expression in prostate cancer cells inhibits tumor growth and metastasis. We experimentally manipulated PTRF expression in three prostate cancer cell lines, namely the caveolin-1 positive cells PC3 and DU145 and the caveolin-1-negative LNCaP cells, to evaluate angiogenesis- and lymphangiogenesis-regulating functions of PTRF. We show that the conditioned medium of PTRF-expressing prostate cancer cells decreases ECs proliferation, migration and differentiation in vitro and ex vivo. This can occur independently from caveolin-1 expression and secretion or caveola formation, since the anti-angiogenic effects of PTRF were detected in caveolin-1-negative LNCaP cells. Additionally, PTRF expression in PC3 cells significantly decreased blood and lymphatic vessel densities in orthotopic tumors in mice. Our results suggest that the absence of PTRF in prostate cancer cells contributes significantly to tumour progression and metastasis by promoting the angiogenesis and lymphangiogenesis potential of the cancer cells, and this could be exploited for therapy.
Keywords: PTRF; caveolae; angiogenesis; lymphangiogenesis; prostate cancer
Description: Published: October 4, 2013
Rights: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.18632/oncotarget.1300
Grant ID: http://purl.org/au-research/grants/nhmrc/511005
http://purl.org/au-research/grants/nhmrc/569542
http://purl.org/au-research/grants/arc/FT120100251
Published version: http://dx.doi.org/10.18632/oncotarget.1300
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