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Type: Journal article
Title: Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke
Author: Turner, R.
Sharp, F.
Citation: Frontiers in Cellular Neuroscience, 2016; 10(MAR2016):56-1-56-13
Publisher: Frontiers Media SA
Issue Date: 2016
ISSN: 1662-5102
Statement of
Renée J. Turner, Frank R. Sharp
Abstract: Numerous studies have documented increases in matrix metalloproteinases (MMPs), specifically MMP-9 levels following stroke, with such perturbations associated with disruption of the blood brain barrier (BBB), increased risk of hemorrhagic complications, and worsened outcome. Despite this, controversy remains as to which cells release MMP-9 at the normal and pathological BBB, with even less clarity in the context of stroke. This may be further complicated by the influence of tissue plasminogen activator (tPA) treatment. The aim of the present review is to examine the relationship between neutrophils, MMP-9 and tPA following ischemic stroke to elucidate which cells are responsible for the increases in MMP-9 and resultant barrier changes and hemorrhage observed following stroke.
Keywords: Neutrophils; MMP-9; tPA; blood-brain barrier; ischemic stroke; hemorrhagic transformation; cerebral edema
Rights: Copyright © 2016 Turner and Sharp. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI: 10.3389/fncel.2016.00056
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