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Type: Journal article
Title: Corticospinal modulation induced by sounds depends on action preparedness
Author: Marinovic, W.
Tresilian, J.R.
de Rugy, A.
Sidhu, S.
Riek, S.
Citation: Journal of Physiology-London, 2014; 592(1):153-169
Publisher: Wiley-Blackwell
Issue Date: 2014
ISSN: 0022-3751
Statement of
Welber Marinovic, James R. Tresilian, Aymar de Rugy, Simranjit Sidhu and Stephan Riek
Abstract: A loud acoustic stimulus (LAS) presented during movement preparation can induce an early release of the prepared action. Because loud sound has been found to have an inhibitory effect on motor cortex excitability, it is possible that the motor cortex plays little role in the early release of prepared responses. We sought to shed new light on this suggestion by probing changes in corticospinal excitability after LAS presentation during preparation for an anticipatory action. Unexpectedly, we show that the changes in corticospinal excitability after LAS presentation are not fixed. Based on the magnitude of motor-evoked potentials elicited by transcranial magnetic and electric stimulation of the motor cortex, we demonstrate that the effects of auditory stimuli on corticospinal excitability depend on the level of readiness for action: inhibition in early preparation and facilitation close to movement onset. We also show that auditory stimuli can regulate intracortical excitability by increasing intracortical facilitation and reducing short-interval intracortical inhibition. Together, these findings indicate that, at least in part, the early release of motor responses by auditory stimuli involves the motor cortex.
Keywords: Motor Cortex
Rights: © 2013 The Authors. The Journal of Physiology © 2013 The Physiological Society
RMID: 0030036387
DOI: 10.1113/jphysiol.2013.254581
Appears in Collections:Physiology publications

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