Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/113537
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Type: Journal article
Title: Fructose acute effects on glucose, insulin, and triglyceride after a solid meal compared with sucralose and sucrose in a randomized crossover study
Author: Gallagher, C.
Keogh, J.
Pedersen, E.
Clifton, P.
Citation: American Journal of Clinical Nutrition, 2016; 103(6):1453-1457
Publisher: Oxford University Press
Issue Date: 2016
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Clare Gallagher, Jennifer B Keogh, Eva Pedersen, and Peter M Clifton
Abstract: Background: Fructose, which is a sweetener with a low glycemic index, has been shown to elevate postprandial triglyceride compared with glucose. There are limited data on the effect of fructose in a solid mixed meal containing starch and protein. Objective: We determined the effects of sucrose, fructose, and sucralose on triglyceride, glucose, and insulin in an acute study in healthy, overweight, and obese individuals. Design: The study had a randomized crossover design. Twenty-seven participants with a mean age of 44 y and a mean body mass index (in kg/m(2)) of 26 completed the study. Fructose (52 g), sucrose (65 g), and sucralose (0.1 g) were delivered as sweet-taste-balanced muffins with a total fat load (66 g). Blood samples were taken at baseline and every 30 min for 4-h glucose, triglyceride, and insulin concentrations, and the area under the curve (AUC) and the incremental area under the curve (iAUC) were analyzed. Results: No significant difference was shown between the 3 sweeteners for triglyceride and glucose concentrations and the AUC. The glucose iAUC was lower for fructose than for sucrose and sucralose (P < 0.05). Insulin concentrations differed significantly by the type of muffin (P = 0.001), the interaction of time by type of muffin (P = 0.035), the AUC (P < 0.001), and the iAUC (P < 0.001). Fructose had a significantly lower insulin response than that of either sucrose (P-treatment = 0.006) or sucralose (P-treatment = 0.041). Conclusions: Fructose, at a moderate dose, did not significantly elevate triglyceride compared with sucrose or sucralose and lowered the glucose iAUC. These results indicate that these sweeteners, at an equivalent sweetness, can be used in normal solid meals. Fructose showed a lower insulin response, which may be beneficial in the long term in individuals at risk of type 2 diabetes.
Keywords: Fructose; insulin; postprandial; sucralose; sucrose
Rights: © 2016 American Society for Nutrition
RMID: 0030070740
DOI: 10.3945/ajcn.115.129866
Appears in Collections:Medicine publications

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