Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/113658
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Type: Journal article
Title: Reduced interleukin-4 receptor α expression on CD8⁺ T cells correlates with higher quality anti-viral immunity
Other Titles: Reduced interleukin-4 receptor alpha expression on CD8(+) T cells correlates with higher quality anti-viral immunity
Author: Wijesundara, D.
Tscharke, D.
Jackson, R.
Ranasinghe, C.
Citation: PLoS One, 2013; 8(1):e55788-1-e55788-11
Publisher: Public Library of Science (PLoS)
Issue Date: 2013
ISSN: 1932-6203
1932-6203
Editor: Turner, S.J.
Statement of
Responsibility: 
Danushka K. Wijesundara, David C. Tscharke, Ronald J. Jackson, Charani Ranasinghe
Abstract: With the hope of understanding how interleukin (IL)-4 and IL-13 modulated quality of anti-viral CD8⁺ T cells, we evaluated the expression of receptors for these cytokines following a range of viral infections (e.g. pox viruses and influenza virus). Results clearly indicated that unlike other IL-4/IL-13 receptor subunits, IL-4 receptor α (IL-4Rα) was significantly down-regulated on anti-viral CD8⁺ T cells in a cognate antigen dependent manner. The infection of gene knockout mice and wild-type (WT) mice with vaccinia virus (VV) or VV expressing IL-4 confirmed that IL-4, IL-13 and signal transducer and activator of transcription 6 (STAT6) were required to increase IL-4Rα expression on CD8⁺ T cells, but not interferon (IFN)-γ. STAT6 dependent elevation of IL-4Rα expression on CD8⁺ T cells was a feature of poor quality anti-viral CD8⁺ T cell immunity as measured by the production of IFN-γ and tumor necrosis factor α (TNF-α) in response to VV antigen stimulation in vitro. We propose that down-regulation of IL-4Rα, but not the other IL-4/IL-13 receptor subunits, is a mechanism by which CD8⁺ T cells reduce responsiveness to IL-4 and IL-13. This can improve the quality of anti-viral CD8⁺ T cell immunity. Our findings have important implications in understanding anti-viral CD8⁺ T cell immunity and designing effective vaccines against chronic viral infections.
Keywords: CD8-Positive T-Lymphocytes
Description: Published January 31, 2013
Rights: © 2013 Wijesundara et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pone.0055788
Grant ID: http://purl.org/au-research/grants/nhmrc/525431
http://purl.org/au-research/grants/nhmrc/1000703
Appears in Collections:Aurora harvest 8
Medicine publications

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