Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/113658
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Type: | Journal article |
Title: | Reduced interleukin-4 receptor α expression on CD8⁺ T cells correlates with higher quality anti-viral immunity |
Other Titles: | Reduced interleukin-4 receptor alpha expression on CD8(+) T cells correlates with higher quality anti-viral immunity |
Author: | Wijesundara, D.K. Tscharke, D.C. Jackson, R.J. Ranasinghe, C. |
Citation: | PLoS One, 2013; 8(1):e55788-1-e55788-11 |
Publisher: | Public Library of Science (PLoS) |
Issue Date: | 2013 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Turner, S.J. |
Statement of Responsibility: | Danushka K. Wijesundara, David C. Tscharke, Ronald J. Jackson, Charani Ranasinghe |
Abstract: | With the hope of understanding how interleukin (IL)-4 and IL-13 modulated quality of anti-viral CD8⁺ T cells, we evaluated the expression of receptors for these cytokines following a range of viral infections (e.g. pox viruses and influenza virus). Results clearly indicated that unlike other IL-4/IL-13 receptor subunits, IL-4 receptor α (IL-4Rα) was significantly down-regulated on anti-viral CD8⁺ T cells in a cognate antigen dependent manner. The infection of gene knockout mice and wild-type (WT) mice with vaccinia virus (VV) or VV expressing IL-4 confirmed that IL-4, IL-13 and signal transducer and activator of transcription 6 (STAT6) were required to increase IL-4Rα expression on CD8⁺ T cells, but not interferon (IFN)-γ. STAT6 dependent elevation of IL-4Rα expression on CD8⁺ T cells was a feature of poor quality anti-viral CD8⁺ T cell immunity as measured by the production of IFN-γ and tumor necrosis factor α (TNF-α) in response to VV antigen stimulation in vitro. We propose that down-regulation of IL-4Rα, but not the other IL-4/IL-13 receptor subunits, is a mechanism by which CD8⁺ T cells reduce responsiveness to IL-4 and IL-13. This can improve the quality of anti-viral CD8⁺ T cell immunity. Our findings have important implications in understanding anti-viral CD8⁺ T cell immunity and designing effective vaccines against chronic viral infections. |
Keywords: | CD8-Positive T-Lymphocytes |
Description: | Published January 31, 2013 |
Rights: | © 2013 Wijesundara et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0055788 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/525431 http://purl.org/au-research/grants/nhmrc/1000703 |
Published version: | http://dx.doi.org/10.1371/journal.pone.0055788 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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hdl_113658.pdf | Published Version | 1.34 MB | Adobe PDF | View/Open |
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