Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/113713
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Type: Journal article
Title: Characterisation of myocardial injury via T1 mapping in early reperfused myocardial infarction and its relationship with global and regional diastolic dysfunction
Author: Azarisman, S.
Carbone, A.
Shirazi, M.
Bradley, J.
Teo, K.
Worthley, M.
Worthley, S.
Citation: Heart Lung and Circulation, 2016; 25(11):1094-1106
Publisher: Elsevier
Issue Date: 2016
ISSN: 1443-9506
1444-2892
Statement of
Responsibility: 
Shah M. Azarisman, Angelo Carbone, Mitra Shirazi, Julie Bradley, Karen S. Teo, Matthew I. Worthley, Stephen G. Worthley
Abstract: Background: Cardiovascular magnetic resonance (CMR) advances in imaging techniques, permits the ability to accurately characterise tissue injury post myocardial infarction. Pre-contrast T1 mapping enables this through measurement of pre-contrast T1 relaxation times. We investigate the relationship between T1 characterisation of myocardial injury with global and regional diastolic function. Methods: Revascularised acute myocardial infarction patients with normal left ventricular (LV) systolic function on TTE were assessed by 1.5T CMR. Acute regional diastolic wall motion abnormalities, global diastolic function measurements, acute segmental damage fraction with LGE and mean segmental pre-contrast T1 values were assessed on matching short axis slices. Results: Forty-four patients were analysed. Mean LVEF was 62.1±9.4%. No difference between NSTEMI (22/44) and STEMI in mean pre-contrast T1 values of infarcted (1025.0±109.2 vs 1011.0±81.6ms, p=0.70), adjacent (948.3±45.3 vs 941.1±46.6ms, p=0.70) and remote (888.8±52.8 vs 881.2±54.5ms, p=0.66) segments was detected. There was no correlation between pre-contrast T1 of infarcted segments with global diastolic dysfunction (E/A, r2=0.216, p=0.06; S/D, r2=0.243, p=0.053; E/E', r2=0.240, p=0.072), but there was significantly positive, moderate correlation with circumferential diastolic strain rate, (r2=0.579, p<0.01) with excellent agreement and reproducibility. Conclusion: Cardiac magnetic resonance evaluation of pre-contrast T1 values revealed no difference between NSTEMI and STEMI patients in terms of tissue characterisation post-myocardial infarction. However, pre-contrast T1 of infarcted tissue is significantly correlated with regional diastolic circumferential strain rate.
Keywords: T1 mapping; MOLLI; diastology; cardiac magnetic resonance
Rights: © 2016 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.
RMID: 0030050053
DOI: 10.1016/j.hlc.2016.03.011
Appears in Collections:Medicine publications

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