Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/113778
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dc.contributor.authorVan Wettere, W.en
dc.contributor.authorWillson, N.en
dc.contributor.authorPain, S.en
dc.contributor.authorForder, R.en
dc.date.issued2016en
dc.identifier.citationAnimal, 2016; 10(10):1655-1659en
dc.identifier.issn1751-7311en
dc.identifier.issn1751-732Xen
dc.identifier.urihttp://hdl.handle.net/2440/113778-
dc.description.abstractA high proportion of piglets fail to adapt to the changing composition of their diet at weaning, resulting in weight loss and increased susceptibility to pathogens. Polyamines are present in sow milk and promote neonatal maturation of the gut. We hypothesised that oral spermine and spermidine supplementation before weaning would increase piglet growth and promote gastrointestinal development at weaning. In Experiment One, one pair of liveweight (LW)-matched piglets per litter from first and third lactation sows received 2 ml of a 0 (Control) or 463 nmol/ml spermine solution at 14, 16, 18, 20 and 22 days of age (n=6 piglets/treatment per parity). Villus height and crypt depth in the duodenum and jejunum were measured at weaning (day 23 postpartum). In Experiment Two, piglets suckling 18 first and 18 third lactation sows were used. Within each litter, piglets received 2 ml of either water (Control), 463 nmol/ml spermine solution or 2013 nmol/ml spermidine solution at 14, 16, 18, 22 and 24 days of age (n=54 piglets/treatment per sow parity). Piglets were weighed individually at 14, 18, 24 (weaning) and 61 days of age. In Experiment One, oral spermine supplementation resulted in a 41% increase in villus height, a 21% decrease in crypt depth and 79% decrease in the villus height : crypt depth ratio compared with control piglets (P<0.01). In Experiment Two, spermine and spermidine-supplemented piglets suckling first lactation sows grew faster (P<0.05) between days 14 and 18 postpartum than control piglets: 0.230±0.011 and 0.227±0.012 v. 0.183±0.012 kg/day, respectively. Spermine supplementation tended (P<0.1) to increase piglet LW gain from weaning to day 37 post-weaning compared with control piglets (0.373±0.009 v. 0.341±0.010 kg/day). In conclusion, spermine supplementation increased villus height at weaning, and appears to have the potential to improve the pre- and post-weaning growth of conventionally weaned piglets.en
dc.description.statementofresponsibilityW.H.E.J. van Wettere, N.-L. Willson, S.J. Pain and R.E.A. Forderen
dc.language.isoenen
dc.publisherCambridge University Pressen
dc.rights© The Animal Consortium 2016en
dc.subjectPiglets; polyamines; gastrointestinal tract; weaning; growthen
dc.titleEffect of oral polyamine supplementation pre-weaning on piglet growth and intestinal characteristicsen
dc.typeJournal articleen
dc.identifier.rmid0030045835en
dc.identifier.doi10.1017/S1751731116000446en
dc.identifier.pubid240441-
pubs.library.collectionAnimal and Veterinary Sciences publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidVan Wettere, W. [0000-0001-8176-4122]en
dc.identifier.orcidWillson, N. [0000-0002-3851-8548]en
Appears in Collections:Animal and Veterinary Sciences publications

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