Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/113809
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Correlation between neonatal outcomes of twins depends on the outcome: secondary analysis of twelve randomised controlled trials
Author: Yelland, L.N.
Schuit, E.
Zamora, J.
Middleton, P.F.
Lim, A.C.
Nassar, A.H.
Rode, L.
Serra, V.
Thom, E.A.
Vayssière, C.
Mol, B.W.
Gates, S.
Citation: BJOG, 2018; 125(11):1406-1413
Publisher: Wiley
Issue Date: 2018
ISSN: 1470-0328
1471-0528
Statement of
Responsibility: 
LN Yelland, E Schuit, J Zamora, PF Middleton, AC Lim, AH Nassar, L Rode, V Serra, EA Thom, C Vayssière, BWJ Mol, S Gates
Abstract: Objective: To estimate the magnitude of the correlation between neonatal outcomes of twins and demonstrate how this information can be used in the design of randomised controlled trials (RCTs) in women with twin pregnancies. Design: Secondary analysis of data from 12 RCTs. Setting: Obstetric care in multiple countries, 2004–2012. Population or sample: 4504 twin pairs born to women who participated in RCTs to assess treatments given during pregnancy. Methods: Intraclass correlation coefficients (ICCs) were estimated using log-binomial and linear models. Main outcome measures: Perinatal death, respiratory distress syndrome, bronchopulmonary dysplasia, intraventricular haemorrhage, necrotising enterocolitis, sepsis, neonatal intensive care unit admission, birthweight, low birthweight and two composite measures of adverse neonatal outcome. Results: ICCs for the composite measures of adverse neonatal outcome were all above 0.5, indicating moderate to strong correlation between adverse outcomes of twins. For individual neonatal outcomes, median ICCs across trials ranged from 0.13 to 0.79 depending on the outcome. An example illustrates how ICCs can be used in sample size calculations for RCTs in women with twin pregnancies. Conclusions: The correlation between neonatal outcomes of twins varies considerably between outcomes and may be lower than expected. Our ICC estimates can be used for designing and analysing RCTs that recruit women with twin pregnancies and for performing meta-analyses that include such RCTs. Researchers are encouraged to report ICCs for neonatal outcomes in twins in their own RCTs.
Keywords: Bayesian analysis; intraclass correlation coefficient; meta-analysis; power; Sample size; twins
Description: Published Online 26 June 2018.
Rights: © 2018 Royal College of Obstetricians and Gynaecologists
RMID: 0030089845
DOI: 10.1111/1471-0528.15292
Appears in Collections:Obstetrics and Gynaecology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.