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Type: Journal article
Title: Genetic localisation of MRX27 to Xq24-26 defines another discrete gene for non-specific X-linked mental retardation
Author: Gedeon, A.
Glass, I.
Connor, J.
Mulley, J.
Citation: American Journal of Medical Genetics, 1996; 64(1):121-124
Publisher: WILEY-LISS
Issue Date: 1996
ISSN: 0148-7299
Abstract: A large family with non-specific X-linked mental retardation (MRX) was first described in 1991 [Glass et al., 1991], with a suggestion of linkage to Xq26-27. The maximum lod score was 1.60 (theta = 0.10) with the F9 locus. The localisation of this MRX gene has now been established by linkage to microsatellite markers. Peak pairwise lod scores of 4.02 and 4.01 (theta = 0.00) were attained at the DXS1114 and DXS994 loci respectively. This MRX gene is now designated MRX27 and is localised to Xq24-26 by recombination events detected by DXS424 and DXS102. This regional localisation spans 26.2 cM on the genetic background map and defines another distinct MRX interval by linkage to a specific region of the X chromosome.
Keywords: X Chromosome; Humans; Chromosome Mapping; Pedigree; Female; Male; Genetic Linkage; Intellectual Disability; Genetic Carrier Screening
RMID: 0030004353
DOI: 10.1002/(SICI)1096-8628(19960712)64:1<121::AID-AJMG20>3.0.CO;2-O
Appears in Collections:Genetics publications

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