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Type: Journal article
Title: Role of the β common (βc) family of cytokines in health and disease
Other Titles: Role of the beta common (beta c) family of cytokines in health and disease
Author: Hercus, T.
Kan, W.
Broughton, S.
Tvorogov, D.
Ramshaw, H.
Sandow, J.
Nero, T.
Dhagat, U.
Thompson, E.
Tung Shing, K.
McKenzie, D.
Wilson, N.
Owczarek, C.
Vairo, G.
Nash, A.
Tergaonkar, V.
Hughes, T.
Ekert, P.
Samuel, M.
Bonder, C.
et al.
Citation: Cold Spring Harbor perspectives in biology, 2018; 10(6):a028514-a028514
Publisher: Cold Spring Harbor Laboratory Press
Issue Date: 2018
ISSN: 1943-0264
Statement of
Timothy R. Hercus, Winnie L. T. Kan, Sophie E. Broughton, Denis Tvorogov, Hayley S. Ramshaw, Jarrod J. Sandow, Tracy L. Nero, Urmi Dhagat, Emma J. Thompson, Karen S. Cheung Tung Shing, Duncan R. McKenzie, Nicholas J. Wilson, Catherine M. Owczarek, Gino Vairo, Andrew D. Nash, Vinay Tergaonkar, Timothy Hughes, Paul G. Ekert, Michael S. Samuel, Claudine S. Bonder, Michele A. Grimbaldeston, Michael W. Parker and Angel F. Lopez
Abstract: The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use βc as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many biological paradigms and structural principles applicable to the IL-2, IL-4, and IL-6 receptor families, all of which also share one or more signaling subunits. Originally identified for their functions in the hematopoietic system, the βc cytokines are now known to be truly pleiotropic, impacting on multiple cell types, organs, and biological systems, and thereby controlling the balance between health and disease. This review will focus on the emerging biological roles for the βc cytokines, our progress toward understanding the mechanisms of receptor assembly and signaling, and the application of this knowledge to develop exciting new therapeutic approaches against human disease.
Keywords: Humans
Signal Transduction
Gene Expression Regulation
Rights: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a028514
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