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Type: Journal article
Title: Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment
Author: Street, S.J.
Parletta, N.
Milte, C.
Sullivan, K.
Hills, A.P.
Buckley, J.
Howe, P.
Citation: Aging and Mental Health, 2015; 19(10):885-891
Publisher: Taylor & Francis
Issue Date: 2015
ISSN: 1360-7863
Statement of
Steven John Street, Natalie Parletta, Catherine Milte, Karen Sullivan, Andrew P. Hills, Jonathan Buckley and Peter Howe
Abstract: Objectives: To evaluate relationships between self-reported physical activity, proportions of long-chain omega-3 polyunsaturated fatty acids (LCn3) in erythrocyte content (percentage of total fatty acids) and risk of mild cognitive impairment (MCI) in older adults. Method: A cross-sectional study was conducted. Community-dwelling male and female (n = 84) participants over the age of 65 years with and without MCI were tested for erythrocyte proportions of the LCn3s eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Physical activity was measured using a validated questionnaire. Results: The interaction between erythrocyte EPA, but not DHA, and increased physical activity was associated with increased odds of a non-MCI classification. Conclusion: An interaction between physical activity and erythrocyte EPA content (percentage of fatty acids) significantly predicted MCI status in older adults. Randomised control trials are needed to examine the potential for supplementation with EPA in combination with increased physical activity to mitigate the risk of MCI in ageing adults.
Keywords: Ageing; mild cognitive impairment; EPA; DHA; physical activity
Rights: © 2014 Taylor & Francis
DOI: 10.1080/13607863.2014.971705
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