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https://hdl.handle.net/2440/11412
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Type: | Journal article |
Title: | Rapid detection of euchromatin by Alu-PRINS: use in clinical cytogenetics |
Author: | Callen, D. Yip, M.Y. Eyre, H. |
Citation: | Chromosome Research: the international journal for all aspects of chromosome and nuclear biology, 1997; 5(2):81-85 |
Publisher: | RAPID SCIENCE PUBLISHERS |
Issue Date: | 1997 |
ISSN: | 0967-3849 1573-6849 |
Abstract: | Alu-PRINS was successful in providing positive identification of euchromatin when oligoprimers were used at either extremity of the consensus Alu sequence. This technique was sensitive, as shown by the ability to detect small regions of euchromatin translocated to the short arm of an acrocentric chromosome. Since the Alu-PRINS technique is rapid and relatively simple, it will be useful in the diagnostic cytogenetics laboratory for the assessment of aberrant short arms of acrocentric satellites. This technique was also useful in defining the structure of small accessory marker chromosomes. |
Keywords: | Centromere Chromatin Euchromatin Humans Chromosome Disorders Chromosome Aberrations DNA Primers In Situ Hybridization, Fluorescence Sensitivity and Specificity Repetitive Sequences, Nucleic Acid Infant Infant, Newborn Female Male |
DOI: | 10.1023/A:1018457806004 |
Published version: | http://dx.doi.org/10.1023/a:1018457806004 |
Appears in Collections: | Aurora harvest 2 Genetics publications |
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