Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/114135
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Type: Journal article
Title: TGF- α overexpression in breast cancer bone metastasis and primary lesions and TGF- α enhancement of expression of procancer metastasis cytokines in bone marrow mesenchymal stem cells
Other Titles: TGF- alpha overexpression in breast cancer bone metastasis and primary lesions and TGF- alpha enhancement of expression of procancer metastasis cytokines in bone marrow mesenchymal stem cells
Author: Sun, J.
Cui, H.
Gao, Y.
Pan, Y.
Zhou, K.
Huang, J.
Lan, J.
Wei, Q.
Liu, X.
Liu, L.
Xian, C.J.
Citation: BioMed Research International, 2018; 2018:6565393-1-6565393-10
Publisher: Hindawi Publishing
Issue Date: 2018
ISSN: 2314-6133
2314-6141
Statement of
Responsibility: 
Jingbo Sun, Haiyan Cui, Yanxin Gao, Yangjian Pan, Kun Zhou, Jingzhan Huang, Jin Lan, Qingzhu Wei, Xiaolong Liu, Lixin Liu and Cory J. Xian
Abstract: Bone metastasis (BM) is the advanced complication of breast cancer, while bone marrow-derived mesenchymal stem cells (BMSCs) in the microenvironment unclearly contribute to cancer metastasis. This study investigated potential roles of transforming growth factor- (TGF-) α in the interaction between breast cancer and BMSCs in BM. Clinical cases of breast cancer with bone metastasis (BMBC), breast cancer without bone metastasis (Non-BM-BC), and benign fibroadenoma (Benign) were enlisted in a retrospective study. TGF-α was found obviously overexpressed in BM lesion of BMBC compared to primary lesion of both BMBC and Non-BM-BC (), and TGF-α was higher in primary lesion of both BMBC and Non-BM-BC () than Benign group. Interestingly, TGF-α in nontumor tissues of both BMBC and Non-BM-BC was at a higher level than Benign group (), and numbers of macrophages in nontumor tissues of both BMBC and Non-BM-BC () were higher than Benign group. Furthermore, in cultured human BMSCs, TGF-α stimulated production of procancer cytokines including IL-6, VEGF, FGF10, FGF17, and TGF-β1 in a dose-dependent manner. Thus, TGF-α in BC could potentially be an important signal of carcinogenesis and metastasis. Macrophages in the nontumor tissue of BC may not be protective but could promote cancer metastasis.
Keywords: Bone Marrow Cells
Mesenchymal Stem Cells
Humans
Bone Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Transforming Growth Factor alpha
Neoplasm Proteins
Cytokines
Aged
Middle Aged
Female
Rights: © 2018 Jingbo Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: 10.1155/2018/6565393
Grant ID: 201604KW011
http://purl.org/au-research/grants/nhmrc/1042105
Appears in Collections:Aurora harvest 3
Medicine publications

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