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Type: Journal article
Title: Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin
Author: Mousa, A.
Abell, S.K.
Shorakae, S.
Harrison, C.L.
Naderpoor, N.
Hiam, D.
Moreno-Asso, A.
Stepto, N.K.
Teede, H.J.
de Courten, B.
Citation: Molecular Nutrition and Food Research, 2017; 61(11):1700488-1-1700488-11
Publisher: Wiley
Issue Date: 2017
ISSN: 1613-4125
Statement of
Aya Mousa, Sally K Abell, Soulmaz Shorakae, Cheryce L Harrison, Negar Naderpoor, Danielle Hiam, Alba Moreno-Asso, Nigel K Stepto, Helena J Teede and Barbora de Courten
Abstract: Scope: Maternal vitamin D deficiency has been implicated in adverse pregnancy outcomes. However, the association between vitamin D and inflammation, particularly adipokines, remains unexplored in pregnancy. Methods and results: In 102 overweight or obese pregnant women at high-risk of gestational diabetes mellitus (GDM), we investigated relationships between maternal 25-hydroxyvitamin D (25(OH)D) concentrations at 12–15 wk gestation (baseline) and serum lipids, inflammatory markers, novel adipokines (omentin-1, visfatin, high molecular weight (HMW) adiponectin), and subsequent pregnancy outcomes (GDM, preeclampsia, preterm birth [PTB]). After adjustment for maternal factors (age, BMI, parity, ethnicity, and smoking status), baseline 25(OH)D concentrations were inversely associated with total cholesterol and triglycerides, and positively associated with HMW-adiponectin. Higher baseline 25(OH)D concentrations were associated with decreased fasting and 1-h post-OGTT glucose and reduced risk of GDM at 26–28 wk, as well as with longer gestation and reduced risk of PTB upon additional adjustment for caesarean section. Adding HMW-adiponectin to the multivariable models attenuated most associations, and HMW-adiponectin was a significant predictor in the models. Conclusion: Our findings suggest that lower maternal 25(OH)D concentrations in overweight/ obese pregnant women at high-risk of GDM are associated with increased cardiometabolic risks during pregnancy and adverse pregnancy outcomes, and that these associations may be mediated by HMW-adiponectin.
Keywords: Adipokines; cardiometabolic risk factors; gestational diabetes mellitus; pregnancy; vitamin D
Rights: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/mnfr.201700488
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