Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/114348
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Type: Journal article
Title: Increased beat-to-beat T-wave variability in myocardial infarction patients
Author: Hasan, M.A.
Abbott, D.
Baumert, M.
Krishnan, S.
Citation: Biomedical Engineering/Biomedizinische Technik, 2018; 63(2):123-130
Publisher: De Gruyter
Issue Date: 2018
ISSN: 0013-5585
1862-278X
Statement of
Responsibility: 
Muhammad A. Hasan, Derek Abbott, Mathias Baumert, Sridhar Krishnan
Abstract: The purpose of this study was to investigate the beat-to-beat variability of T-waves (TWV) and to assess the diagnostic capabilities of T-wave-based features for myocardial infarction (MI). A total of 148 recordings of standard 12-lead electrocardiograms (ECGs) from 79 MI patients (22 females, mean age 63±12 years; 57 males, mean age 57±10 years) and 69 recordings from healthy subjects (HS) (17 females, 42±18 years; 52 males, 40±13 years) were studied. For the quantification of beat-to-beat QT intervals in ECG signal, a template-matching algorithm was applied. To study the T-waves beat-to-beat, we measured the angle between T-wave max and T-wave end with respect to Q-wave (∠α) and T-wave amplitudes. We computed the standard deviation (SD) of beat-to-beat T-wave features and QT intervals as markers of variability in T-waves and QT intervals, respectively, for both patients and HS. Moreover, we investigated the differences in the studied features based on gender and age for both groups. Significantly increased TWV and QT interval variability (QTV) were found in MI patients compared to HS (p<0.05). No significant differences were observed based on gender or age. TWV may have some diagnostic attributes that may facilitate identifying patients with MI. In addition, the proposed beat-to-beat angle variability was found to be independent of heart rate variations. Moreover, the proposed feature seems to have higher sensitivity than previously reported feature (QT interval and T-wave amplitude) variability for identifying patients with MI.
Keywords: Electrocardiogram (ECG); QT interval; repolarization; T-wave alternans; T-wave
Rights: © 2018 Walter de Gruyter GmbH, Berlin/Boston
RMID: 0030084036
DOI: 10.1515/bmt-2015-0186
Appears in Collections:Electrical and Electronic Engineering publications

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