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Type: Journal article
Title: Characterisation and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer
Author: Whitmore, S.
Settasatian, C.
Crawford, J.
Lower, K.
McCallum, B.
Seshadri, R.
Cornelisse, C.
Moerland, E.
Cleton-Jansen, A.M.
Tipping, A.
Mathew, C.
Savnio, M.
Savoia, A.
Verlander, P.
Auerbach, A.
Van Berkel, C.
Pronk, J.
Doggett, N.
Callen, D.
Citation: Genomics, 1998; 52(3):325-331
Publisher: Elsevier
Issue Date: 1998
ISSN: 0888-7543
Statement of
Scott A. Whitmore, Chatri Settasatian, Joanna Crawford, Karen M. Lower, Brett McCallum, Ram Seshadri, Cees J. Cornelisse, Elna W. Moerland, Anne-Marie Cleton-Jansen, Alex J. Tipping, Christopher G. Mathew, Maria Savnio, Anna Savoia, Peter Verlander, Arleen D. Auerbach, Carola Van Berkel, Jan C. Pronk, Norman A. Doggett and David F. Callen
Abstract: Loss of heterozygosity involving the long arm of chromosome 16 is a frequent event seen in a number of human carcinomas, including breast, prostate, hepatocellular, and ovarian cancers. A region found to be commonly deleted in breast and prostate carcinomas is located at 16q24.3, which suggests the presence of a tumor suppressor gene that may be altered in these two malignancies. A detailed physical and transcription map of this region that includes the loci defining the smallest region of deletion has been constructed. This report describes the characterization of a transcript located in this region, the growth arrest-specific 11 (GAS11) gene, which was viewed as a potential tumor suppressor gene due to the expression of its mouse homolog specifically during growth arrest. The gene consists of 11 exons spanning approximately 25 kb. Northern blot analysis identified two ubiquitously expressed mRNAs of 3.4 and 1.8 kb produced by the use of alternative polyadenylation sites. Another gene,C16orf3(chromosome 16 open reading frame 3), was found to lie within intron 2 ofGAS11.This gene appears intronless, is transcribed in the orientation opposite to that ofGAS11,and is expressed at low levels. These genes were examined for mutations in breast tumor DNA, and both were excluded as tumor suppressor genes involved in breast cancer.
Keywords: Chromosomes, Human, Pair 16; Humans; Breast Neoplasms; Cytoskeletal Proteins; Neoplasm Proteins; RNA, Messenger; DNA Primers; Restriction Mapping; Cloning, Molecular; Sequence Analysis, DNA; Gene Expression Regulation, Neoplastic; RNA Splicing; Base Sequence; Loss of Heterozygosity; Alleles; Genes, Tumor Suppressor; Open Reading Frames; Molecular Sequence Data; Female; RNA, Long Noncoding
Rights: Copyright © 1998 Academic Press. All rights reserved.
RMID: 0030004308
DOI: 10.1006/geno.1998.5457
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Appears in Collections:Genetics publications

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