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Type: Journal article
Title: The antimicrobial activity of mononuclear ruthenium(II) complexes containing the dppz ligand
Author: Liu, X.
Sun, B.
Kell, R.
Southam, H.
Butler, J.
Li, X.
Poole, R.
Keene, F.
Collins, J.
Citation: ChemPlusChem, 2018; 83(7):643-650
Publisher: Wiley-VCH Verlag
Issue Date: 2018
ISSN: 2192-6506
Statement of
Xuewen Liu, Biyun Sun, Ruby E. M. Kell, Hannah M. Southam, Jonathan A. Butler, Xin Li, Robert K. Poole, F. Richard Keene, and J. Grant Collins
Abstract: The cis‐α isomer of [Ru(bb₇)(dppz)]²⁺ (dppz=dipyrido[3,2‐a:2′,3′‐c]phenazine; bb7=bis[4(4′‐methyl‐2,2′‐bipyridyl)]‐1,7‐alkane) has been synthesised. The minimum inhibitory concentrations and the minimum bactericidal concentrations of [Ru(bb₇)(dppz)]²⁺ and its parent complex [Ru(phen)₂(dppz)]²⁺ (phen=1,10‐phenanthroline) were determined against a range of bacteria. The results showed that both ruthenium complexes exhibited good activity against Gram‐positive bacteria, but [Ru(bb₇)(dppz)]²⁺ showed at least eightfold better activity against the Gram‐negative bacteria than [Ru(phen)₂(dppz)]²⁺. Luminescence assays demonstrated that [Ru(bb₇)(dppz)]²⁺ accumulated in a Gram‐negative bacterium to the same degree as in a Gram‐positive species, and assays with liposomes showed that [Ru(bb₇)(dppz)]²⁺ interacted more strongly with membranes than the parent [Ru(phen)₂(dppz)]²⁺ complex. The DNA binding affinity for [Ru(bb₇)(dppz)]²⁺ was determined to be 6.7 × 10⁶ m⁻¹. Although more toxic to eukaryotic cells than [Ru(phen)₂(dppz)]²⁺, [Ru(bb₇)(dppz)]²⁺ exhibited greater activity against bacteria than eukaryotic cells.
Keywords: DNA binding; antimicrobial agents; bioinorganic chemistry; lipophilicity; ruthenium
Description: In memory of Leone Spiccia. This article is part of the Leone Spiccia Memorial Issue. To view the complete issue, visit: Version of record online: April 20, 2018.
Rights: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
RMID: 0030095623
DOI: 10.1002/cplu.201800042
Appears in Collections:Chemistry publications

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