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|Title:||The antimicrobial activity of mononuclear ruthenium(II) complexes containing the dppz ligand|
|Citation:||ChemPlusChem, 2018; 83(7):643-650|
|Xuewen Liu, Biyun Sun, Ruby E. M. Kell, Hannah M. Southam, Jonathan A. Butler, Xin Li, Robert K. Poole, F. Richard Keene, and J. Grant Collins|
|Abstract:||The cis‐α isomer of [Ru(bb₇)(dppz)]²⁺ (dppz=dipyrido[3,2‐a:2′,3′‐c]phenazine; bb7=bis[4(4′‐methyl‐2,2′‐bipyridyl)]‐1,7‐alkane) has been synthesised. The minimum inhibitory concentrations and the minimum bactericidal concentrations of [Ru(bb₇)(dppz)]²⁺ and its parent complex [Ru(phen)₂(dppz)]²⁺ (phen=1,10‐phenanthroline) were determined against a range of bacteria. The results showed that both ruthenium complexes exhibited good activity against Gram‐positive bacteria, but [Ru(bb₇)(dppz)]²⁺ showed at least eightfold better activity against the Gram‐negative bacteria than [Ru(phen)₂(dppz)]²⁺. Luminescence assays demonstrated that [Ru(bb₇)(dppz)]²⁺ accumulated in a Gram‐negative bacterium to the same degree as in a Gram‐positive species, and assays with liposomes showed that [Ru(bb₇)(dppz)]²⁺ interacted more strongly with membranes than the parent [Ru(phen)₂(dppz)]²⁺ complex. The DNA binding affinity for [Ru(bb₇)(dppz)]²⁺ was determined to be 6.7 × 10⁶ m⁻¹. Although more toxic to eukaryotic cells than [Ru(phen)₂(dppz)]²⁺, [Ru(bb₇)(dppz)]²⁺ exhibited greater activity against bacteria than eukaryotic cells.|
|Keywords:||DNA binding; antimicrobial agents; bioinorganic chemistry; lipophilicity; ruthenium|
|Description:||In memory of Leone Spiccia. This article is part of the Leone Spiccia Memorial Issue. To view the complete issue, visit: https://doi.org/10.1002/cplu.v83.7. Version of record online: April 20, 2018.|
|Rights:||© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim|
|Appears in Collections:||Chemistry publications|
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