Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/114723
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Scaling of morphology and ultrastructure of hearts among wild African antelope
Author: Snelling, E.
Maloney, S.
Farrell, A.
Meyer, L.
Izwan, A.
Fuller, A.
Mitchell, D.
Haw, A.
Costello, M.
Seymour, R.
Citation: Journal of Experimental Biology, 2018; 221(17):jeb.184713-1-jeb.184713-9
Publisher: Company of Biologists
Issue Date: 2018
ISSN: 0022-0949
1477-9145
Statement of
Responsibility: 
Edward P. Snelling, Shane K. Maloney, Anthony P. Farrell, Leith C. R. Meyer, Adian Izwan, Andrea Fuller, Duncan Mitchell, Anna Haw, Mary-Ann Costello and Roger S. Seymour
Abstract: The hearts of smaller mammals tend to operate at higher mass-specific mechanical work rates than those of largermammals. The ultrastructural characteristics of the heart that allow for such variation in work rate are still largely unknown. We have used perfusion-fixation, transmission electron microscopy and stereology to assess the morphology and anatomical aerobic power densityof the heart as a function of bodymass across six species of wild African antelope differing by approximately 20-fold in body mass. The survival of wild antelope, as prey animals, depends on competent cardiovascular performance. We found that relative heart mass (g kg⁻¹ body mass) decreases with body mass according to a power equation with an exponent of −0.12±0.07 (±95% confidence interval). Likewise, capillary length density (km cm⁻³ of cardiomyocyte), mitochondrial volume density (fraction of cardiomyocyte) and mitochondrial inner membrane surface density (m² cm⁻³ of mitochondria) also decrease with body mass with exponents of −0.17±0.16, −0.06±0.05 and −0.07±0.05, respectively, trends likely to be associated with the greatermass-specific mechanical work rate of the heart in smaller antelope. Finally, we found proportionality between quantitative characteristics of a structure responsible for the delivery of oxygen (total capillary length) and those of a structure that ultimately uses that oxygen (total mitochondrial inner membrane surface area), which provides support for the economic principle of symmorphosis at the cellular level of the oxygen cascade in an aerobic organ.
Keywords: Capillarity; cardiac; mammal; mitochondria; myofibrils; predation
Rights: © 2018. Published by The Company of Biologists Ltd
RMID: 0030098399
DOI: 10.1242/jeb.184713
Grant ID: http://purl.org/au-research/grants/arc/DP120102081
Appears in Collections:Earth and Environmental Sciences publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.