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dc.contributor.authorThomas, Belinda Jane-
dc.description.abstractInvestigates the histological and molecular changes that occur to the growth plate and defect site following the Langenskiöld procedure (a surgical treatment for growth plate injuries that involves the removal of the bone bridge and replacement with autologous fat.) in the presence and absence of recombinant human OP-1. A sheep model was used in which a section of the growth plate was ablated and filled with autologous fat. Administration of rhOP-1 in conjunction with the Langenskiöld procedure initiated a complex response in the growth plate adjacent to the defect. There was a significant increase in growth plate height, but also accelerated the osteogenic response observed in untreated animals.en
dc.subjectBones -- Growth -- Animal models; Growth plate -- Physiology; Transforming growth factors-beta -- Physiological effecten
dc.titleThe effect of recombinant human osteogenic protein-1 on growth plate repair in a sheep modelen
dc.contributor.schoolDept. of Paediatricsen
dc.provenanceThis electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at:
dc.description.dissertationThesis (Ph.D.) -- University of Adelaide, Dept. of Paediatrics, 2004.en
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