Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/114797
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism
Author: Zheng, P.
Zeng, B.
Zhou, C.
Liu, M.
Fang, Z.
Xu, X.
Zeng, L.
Chen, J.
Fan, S.
Du, X.
Zhang, X.
Yang, D.
Yang, Y.
Meng, H.
Li, W.
Melgiri, N.
Licinio, J.
Wei, H.
Xie, P.
Citation: Molecular Psychiatry, 2016; 21(6):786-796
Publisher: Nature Publishing Group
Issue Date: 2016
ISSN: 1359-4184
1476-5578
Statement of
Responsibility: 
P Zheng, B Zeng, C Zhou, M Liu, Z Fang, X Xu, L Zeng, J Chen, S Fan, X Du, X Zhang, D Yang, Y Yang, H Meng, W Li, N D Melgiri, J Licinio, H Wei and P Xie
Abstract: Major depressive disorder (MDD) is the result of complex gene-environment interactions. According to the World Health Organization, MDD is the leading cause of disability worldwide, and it is a major contributor to the overall global burden of disease. However, the definitive environmental mechanisms underlying the pathophysiology of MDD remain elusive. The gut microbiome is an increasingly recognized environmental factor that can shape the brain through the microbiota-gut-brain axis. We show here that the absence of gut microbiota in germ-free (GF) mice resulted in decreased immobility time in the forced swimming test relative to conventionally raised healthy control mice. Moreover, from clinical sampling, the gut microbiotic compositions of MDD patients and healthy controls were significantly different with MDD patients characterized by significant changes in the relative abundance of Firmicutes, Actinobacteria and Bacteroidetes. Fecal microbiota transplantation of GF mice with 'depression microbiota' derived from MDD patients resulted in depression-like behaviors compared with colonization with 'healthy microbiota' derived from healthy control individuals. Mice harboring 'depression microbiota' primarily exhibited disturbances of microbial genes and host metabolites involved in carbohydrate and amino acid metabolism. This study demonstrates that dysbiosis of the gut microbiome may have a causal role in the development of depressive-like behaviors, in a pathway that is mediated through the host's metabolism.
Keywords: Animals; Humans; Mice; Depression; Depressive Disorder, Major; Gene-Environment Interaction; Microbiota; Dysbiosis; Gastrointestinal Microbiome
Rights: © 2016, Springer Nature
RMID: 0030048317
DOI: 10.1038/mp.2016.44
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.