Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKourghi, M.-
dc.contributor.authorPei, J.-
dc.contributor.authorDe Ieso, M.-
dc.contributor.authorNourmohammadi, S.-
dc.contributor.authorChow, P.-
dc.contributor.authorYool, A.-
dc.identifier.citationClinical and Experimental Pharmacology and Physiology, 2018; 45(4):401-409-
dc.description.abstractAquaporin (AQP) channels in the Major Intrinsic Protein (MIP) family are known to facilitate transmembrane water fluxes in prokaryotes and eukaryotes. Some classes of AQPs also conduct ions, glycerol, urea, CO₂ , nitric oxide, and other small solutes. Ion channel activity has been demonstrated for mammalian AQPs 0, 1, 6, Drosophila big brain (BIB), soybean nodulin 26, and rockcress AtPIP2;1. More classes are likely to be discovered. Newly identified blockers are providing essential tools for establishing physiological roles of some of the AQP dual water and ion channels. For example, the arylsulfonamide AqB011 which selectively blocks the central ion pore of mammalian AQP1 has been shown to impair migration of HT29 colon cancer cells. Traditional herbal medicines are sources of selective AQP1 inhibitors that also slow cancer cell migration. The finding that plant AtPIP2;1 expressed in root epidermal cells mediates an ion conductance regulated by calcium and protons provided insight into molecular mechanisms of environmental stress responses. Expression of lens MIP (AQP0) is essential for maintaining the structure, integrity and transparency of the lens, and Drosophila BIB contributes to neurogenic signalling pathways to control the developmental fate of fly neuroblast cells; however, the ion channel roles remain to be defined for MIP and BIB. A broader portfolio of pharmacological agents is needed to investigate diverse AQP ion channel functions in situ. Understanding the dual water and ion channel roles of AQPs could inform the development of novel agents for rational interventions in diverse challenges from agriculture to human health. This article is protected by copyright. All rights reserved.-
dc.description.statementofresponsibilityMohamad Kourghi, Jinxin V. Pei, Michael L. De Ieso, Saeed Nourmohammadi, Pak Hin Chow, Andrea J. Yool-
dc.rights© 2017 John Wiley & Sons Australia, Ltd-
dc.subjectcation channel-
dc.subjectdivalent cation-
dc.subjectfluid homeostasis-
dc.subjectmajor intrinsic protein-
dc.subjecttraditional herbal medicine-
dc.subjectvolume regulation-
dc.subjectwater channel-
dc.titleFundamental structural and functional properties of Aquaporin ion channels found across the kingdoms of life-
dc.typeJournal article-
dc.identifier.orcidPei, J. [0000-0003-2453-929X]-
dc.identifier.orcidNourmohammadi, S. [0000-0002-9469-2874]-
dc.identifier.orcidYool, A. [0000-0003-1283-585X]-
Appears in Collections:Aurora harvest 3
Molecular and Biomedical Science publications

Files in This Item:
File Description SizeFormat 
hdl_114822.pdfAccepted version858.84 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.