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https://hdl.handle.net/2440/114846
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Type: | Journal article |
Title: | Assessing disutility associated with diabetic retinopathy, diabetic macular oedema and associated visual impairment using the Vision and Quality of Life Index |
Author: | Fenwick, E.K. Xie, J. Pesudovs, K. Ratcliffe, J. Chiang, P.P.C. Finger, R.P. Lamoureux, E.L. |
Citation: | Clinical and Experimental Optometry, 2012; 95(3):362-370 |
Publisher: | Wiley |
Issue Date: | 2012 |
ISSN: | 0816-4622 1444-0938 |
Statement of Responsibility: | Eva K Fenwick, Jing Xie, Konrad Pesudovs, Julie Ratcliffe, Peggy PC Chiang, Robert P Finger, Ecosse L Lamoureux |
Abstract: | BACKGROUND: Use of generic multi-attribute utility instruments (MAUI) to assess the impact of diabetic retinopathy (DR) on health-related quality of life (HRQoL) has produced inconsistent findings. Therefore, we assessed the impact of DR, diabetic macular oedema (DME) and associated visual impairment on vision-related QoL (VRQoL) using a vision-specific MAUI. METHODS: In this cross-sectional study, 203 diabetic patients were recruited from specialised eye clinics in a Melbourne tertiary eye hospital. Severity of combined DR/DME was categorised as: no DR/no DME, mild non-proliferative DR (NPDR) and/or mild DME; moderate NPDR and/or moderate DME and vision-threatening DR (severe NPDR or proliferative DR (PDR) and/or severe DME) in the worse eye. Visual impairment was categorised as: none (up to 0.18 logMAR); mild (from 0.18 to 0.3 logMAR); moderate (from 0.3 to 0.48 logMAR); severe (from 0.48 to 0.78 logMAR); and profound (worse than 0.78 logMAR). The Vision and Quality of Life Index (VisQoL) vision-specific MAUI was the main outcome measure. As the distribution of the utilities was skewed, independent associations with covariates were explored using multivariable quantile regression models (five groups: 15(th) , 30(th) , 45(th) , 60(th) and 75(th) percentiles) ranging from poorest to highest VRQoL. RESULTS: Participants' median age was 65 years (range: 27 to 90 years). Of the 203 participants, 50 (24.6 per cent) had no DR/DME, 24 (11.8 per cent) had mild NPDR/DME, 47 (23.2 per cent) had moderate NPDR/DME and 82 (40.4 per cent) had vision-threatening DR. After adjusting for relevant covariables, only profound visual impairment was independently associated with VisQoL utilities (β= -0.297 ± 0.098 p < 0.01). Severity of DR/DME was not significantly associated with any group of VisQoL utilities. CONCLUSION: The variation in VisQoL utilities was attributed to profound visual impairment but not mild, moderate or severe visual impairment or DR/DME severity. These findings support the use of vision-specific MAUI to capture the impact of profound visual impairment associated with DR and DME. A DR-specific MAUI might be required to assess the specific utility deficits associated with DR/DME across the spectrum of the condition. |
Keywords: | Diabetes; low vision; retina; retinopathy; visual acuity |
Rights: | © 2012 The Authors. Clinical and Experimental Optometry © 2012 Optometrists Association Australia |
DOI: | 10.1111/j.1444-0938.2012.00742.x |
Grant ID: | http://purl.org/au-research/grants/nhmrc/529923 http://purl.org/au-research/grants/arc/LP0884108 |
Published version: | http://dx.doi.org/10.1111/j.1444-0938.2012.00742.x |
Appears in Collections: | Aurora harvest 3 Public Health publications |
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