Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/114929
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Type: Journal article
Title: Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases
Author: Sundaraneedi, M.
Eichenberger, R.
Al-Hallaf, R.
Yang, D.
Sotillo, J.
Rajan, S.
Wangchuk, P.
Giacomin, P.
Keene, F.
Loukas, A.
Collins, J.
Pearson, M.
Citation: International Journal for Parasitology: Drugs and Drug Resistance, 2018; 8(1):1-7
Publisher: Elsevier
Issue Date: 2018
ISSN: 2211-3207
2211-3207
Statement of
Responsibility: 
Madhu Sundaraneedi, , Ramon M. Eichenberger, Rafid Al-Hallaf, Dai Yang, Javier Sotillo, Siji Rajan, Phurpa Wangchuk, Paul R. Giacomin, F. Richard Keene, Alex Loukas, J. Grant Collinsa, Mark S. Pearson
Abstract: Over 4.5 billion people are at risk of infection with soil transmitted helminths and there are concerns about the development of resistance to the handful of frontline nematocides in endemic populations. We investigated the anti-nematode efficacy of a series of polypyridylruthenium(II) complexes and showed they were active against L3 and adult stages of Trichuris muris, the rodent homologue of the causative agent of human trichuriasis, T. trichiura. One of the compounds, Rubb12-mono, which was among the most potent in its ability to kill L3 (IC50 = 3.1 ± 0.4 μM) and adult (IC50 = 5.2 ± 0.3 μM) stage worms was assessed for efficacy in a mouse model of trichuriasis by administering 3 consecutive daily oral doses of the drug 3 weeks post infection with the murine whipworm Trichuris muris. Mice treated with Rubb12-mono showed an average 66% reduction (P = 0.015) in faecal egg count over two independent trials. The drugs partially exerted their activity through inhibition of acetylcholinesterases, as worms treated in vitro and in vivo showed significant decreases in the activity of this class of enzymes. Our data show that ruthenium complexes are effective against T. muris, a model gastro-intestinal nematode and soil-transmitted helminth. Further, knowledge of the target of ruthenium drugs can facilitate modification of current compounds to identify analogues which are even more effective and selective against Trichuris and other helminths of human and veterinary importance.
Keywords: Acetylcholinesterase; Anthelmintic; Ruthenium complex; Trichuris muris
Rights: © 2017 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
RMID: 0030078541
DOI: 10.1016/j.ijpddr.2017.11.005
Appears in Collections:IPAS publications
Physics publications

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