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Type: Journal article
Title: AZT blocks down-regulation of IL-2 and IFN-γ gene expression in HIV acutely infected cells
Other Titles: AZT blocks down-regulation of IL-2 and IFN-gamma gene expression in HIV acutely infected cells
Author: Fan, J.
Li, P.
Kok, T.
Burrell, C.
Citation: Archives of Virology, 1997; 142(5):1035-1043
Issue Date: 1997
ISSN: 0304-8608
Statement of
J. Fan, P. Li, T.-W. Kok, C. J. Burrell
Abstract: HIV infection causes dysregulation of cytokine gene expression in CD4⁺ T cells of the infected host. Azidothymidine (AZT) inhibits HIV repli-cation by blocking reverse transcription. Using a one-stop cell-to-cell HIV infection model, we have investigated the expression of several key cytokines in HIV infected T cells in the absence or presence of AZT treatment. Acute HIV infection of T cells resulted in dramatic down regulation of the expression of IL-2 and INFg mRNA. While β-actin mRNA levels remained constant in both AZT-free and AZT treated cultures after HIV infection, it was found that AZT blocked the down regulation of IL-2 mRNA and INFg mRNA in CD4⁺ T cells acutely infected with HIV.
Keywords: CD4-Positive T-Lymphocytes; Humans; HIV Infections; RNA, Messenger; Zidovudine; Interleukin-2; Down-Regulation; Interferon-gamma
RMID: 0030004257
DOI: 10.1007/s007050050139
Appears in Collections:Microbiology and Immunology publications

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