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|Title:||AZT blocks down-regulation of IL-2 and IFN-γ gene expression in HIV acutely infected cells|
|Other Titles:||AZT blocks down-regulation of IL-2 and IFN-gamma gene expression in HIV acutely infected cells|
|Citation:||Archives of Virology, 1997; 142(5):1035-1043|
|J. Fan, P. Li, T.-W. Kok, C. J. Burrell|
|Abstract:||HIV infection causes dysregulation of cytokine gene expression in CD4⁺ T cells of the infected host. Azidothymidine (AZT) inhibits HIV repli-cation by blocking reverse transcription. Using a one-stop cell-to-cell HIV infection model, we have investigated the expression of several key cytokines in HIV infected T cells in the absence or presence of AZT treatment. Acute HIV infection of T cells resulted in dramatic down regulation of the expression of IL-2 and INFg mRNA. While β-actin mRNA levels remained constant in both AZT-free and AZT treated cultures after HIV infection, it was found that AZT blocked the down regulation of IL-2 mRNA and INFg mRNA in CD4⁺ T cells acutely infected with HIV.|
|Keywords:||CD4-Positive T-Lymphocytes; Humans; HIV Infections; RNA, Messenger; Zidovudine; Interleukin-2; Down-Regulation; Interferon-gamma|
|Appears in Collections:||Microbiology and Immunology publications|
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