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Type: Journal article
Title: Cell adhesion molecules are altered during irinotecan-induced mucositis: a qualitative histopathological study
Author: Al-Dasooqi, N.
Bowen, J.
Bennett, C.
Finnie, J.
Keefe, D.
Gibson, R.
Citation: Supportive Care in Cancer, 2017; 25(2):391-398
Publisher: Springer-Verlag
Issue Date: 2017
ISSN: 0941-4355
Statement of
Noor Al-Dasooqi, Joanne Bowen, Colin Bennett, John Finnie, Dorothy Keefe, Rachel Gibson
Abstract: Purpose: Chemotherapy-induced mucositis is characterised by damage to mucous membranes throughout the alimentary tract. This study aims to investigate the expression of cell adhesion molecules (CAMs) following treatment with irinotecan. Methods: Dark agouti rats received a single dose of 175 mg/kg irinotecan and sacrificed at various time points after treatment. Picro-sirius red staining indicated an increase in collagen around crypts from 24 h in both small and large intestinal regions and this diminished at the later time points. CAMs E-cadherin, P-selectin, E-selectin and integrin-α1 were examined using immunohistochemistry. Results: E-cadherin was significantly elevated in jejunal crypts at the time of maximal tissue damage (48 h), while it decreased at the healing phase (96 h) in both jejunum and colon. P-selectin expression decreased significantly in the jejunum following irinotecan. Crypt expression of E-selectin was significantly elevated in the healing phase of mucositis (96 h). Integrin-α1 expression was significantly altered during the time course in the villus (p = 0.0032) and lamina propria (p = 0.039). Conclusions: Irinotecan induced a significant alteration in CAM expression in the jejunum and colon. Changes in adhesion molecule expression may have a direct impact on the loss of mucosal layer integrity seen in mucositis.
Keywords: Alimentary tract
Adhesion proteins
Description: Published online: 20 September 2016
Rights: © Springer-Verlag Berlin Heidelberg 2016
DOI: 10.1007/s00520-016-3413-x
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