Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/115508
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dc.contributor.authorNarayan, D.en
dc.contributor.authorWood, J.en
dc.contributor.authorChidlow, G.en
dc.contributor.authorCasson, R.en
dc.date.issued2016en
dc.identifier.citationActa Ophthalmologica, 2016; 94(8):748-754en
dc.identifier.issn1755-375Xen
dc.identifier.issn1755-3768en
dc.identifier.urihttp://hdl.handle.net/2440/115508-
dc.description.abstractRetinitis pigmentosa (RP) is an inherited condition that features degeneration of rod and cone photoreceptors. In all forms of RP, the genetic mutation is expressed exclusively in rods; however, cones die too. The secondary death of cones in RP remains somewhat mysterious. A better understanding of the mechanisms that cause cone degeneration in RP could lead to novel treatments that preserve cones. There are a number of prevailing theories that attempt to explain cone degeneration in RP. One concept is that cone survival is dependent on trophic factors produced by rods. Another hypothesis is that cones suffer from a nutrient shortage after rods have been lost. Additionally, oxidative stress and pro-inflammatory microglial activation have also been suggested to play a role in cone death. The present review evaluates the evidence supporting these theories and provides an update on the mechanisms of cone degeneration in RP.en
dc.description.statementofresponsibilityDaniel S. Narayan, John P. M. Wood, Glyn Chidlow, Robert J. Cassonen
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.rights© 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltden
dc.subjectCones; microglia; oxidative stress; RdCVF; retinitis pigmentosa; trophic factorsen
dc.titleA review of the mechanisms of cone degeneration in retinitis pigmentosaen
dc.typeJournal articleen
dc.identifier.rmid0030058406en
dc.identifier.doi10.1111/aos.13141en
dc.identifier.pubid255458-
pubs.library.collectionOpthalmology & Visual Sciences publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidChidlow, G. [0000-0001-7371-0239]en
dc.identifier.orcidCasson, R. [0000-0003-2822-4076]en
Appears in Collections:Opthalmology & Visual Sciences publications

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